| UniProt Protein Function: | Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo. |
| NCBI Summary: | The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of this gene is associated with various forms of cancer, and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. Inhibitors of this gene have also been shown to be effective for the treatment of obesity. A pseudogene of this gene is located on chromosome 2. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015] |
| UniProt Code: | P50579 |
| NCBI GenInfo Identifier: | 5803092 |
| NCBI Gene ID: | 10988 |
| NCBI Accession: | NP_006829 |
| UniProt Related Accession: | P50579 |
| Molecular Weight: | 53kDa |
| NCBI Full Name: | methionine aminopeptidase 2 isoform 1 |
| NCBI Synonym Full Names: | methionyl aminopeptidase 2 |
| NCBI Official Symbol: | METAP2 |
| NCBI Official Synonym Symbols: | MAP2; MNPEP; p67eIF2 |
| NCBI Protein Information: | methionine aminopeptidase 2 |
| UniProt Protein Name: | Methionine aminopeptidase 2 |
| UniProt Synonym Protein Names: | Initiation factor 2-associated 67 kDa glycoproteinUniRule annotationManual assertion according to rulesiHAMAP-Rule:MF_03175; p67UniRule annotationManual assertion according to rulesiHAMAP-Rule:MF_03175; p67eIF2UniRule annotationManual assertion according to rulesiHAMAP-Rule:MF_03175; Peptidase MUniRule annotationManual assertion according to rulesiHAMAP-Rule:MF_03175 |
| UniProt Gene Name: | METAP2 |
