| バックグラウンド: | Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine. |
| UniProt Protein Function: | Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components. |
| NCBI Summary: | Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine. [provided by RefSeq, Oct 2011] |
| UniProt Code: | Q16820 |
| NCBI GenInfo Identifier: | 815890920 |
| NCBI Gene ID: | 4225 |
| NCBI Accession: | NP_001295100.1 |
| UniProt Secondary Accession: | Q16820,Q670J1, B7ZM35, B9EGL6, |
| UniProt Related Accession: | Q16820 |
| Molecular Weight: | 79,571 Da |
| NCBI Full Name: | meprin A subunit beta isoform 2 |
| NCBI Synonym Full Names: | meprin A subunit beta |
| NCBI Official Symbol: | MEP1B |
| NCBI Protein Information: | meprin A subunit beta |
| UniProt Protein Name: | Meprin A subunit beta |
| UniProt Synonym Protein Names: | Endopeptidase-2; Meprin B; N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta; PABA peptide hydrolase; PPH beta |
| Protein Family: | Meprin |
| UniProt Gene Name: | MEP1B |
