Anti-MEKK3 Antibody (CAB3695)
- SKU:
- CAB3695
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- MAPKKK3
- Synonyms:
- MEKK3
Frequently bought together:
Description
| 抗体名: | MEKK3 Rabbit mAb |
| 抗体コード: | CAB3695 |
| サイズ: | 20uL, 50uL, 100uL |
| 同義語: | MAPKKK3, MEKK3 |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthesized peptide derived from human MEKK3 |
| 申し込み: | WB |
| 推奨される希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | HeLa, NIH/3T3, Jurkat, SH-SY5Y, Mouse spleen |
| 免疫原: | A synthesized peptide derived from human MEKK3 |
| 精製方法: | Affinity purification |
| 保管所: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 4215 |
| Uniprot: | Q99759 |
| 計算された分子量: | 71kDa |
| 観察された分子量: | 78kDa |
| UniProt Protein Function: | MEKK3: a protein kinase of the STE11 family. Phosphorylated and activated by MLK3 and TAK1. Phosphorylates and activates MEK5. |
| UniProt Protein Details: | Protein type:Protein kinase, STE; Kinase, protein; EC 2.7.11.25; Protein kinase, Ser/Thr (non-receptor); STE group; STE11 family Chromosomal Location of Human Ortholog: 17q23.3 Cellular Component: intracellular; cytosol Molecular Function:MAP kinase kinase activity; protein binding; MAP kinase kinase kinase activity; metal ion binding; ATP binding; protein kinase activity Biological Process: blood vessel development; positive regulation of I-kappaB kinase/NF-kappaB cascade; activation of MAPKK activity; activation of MAPK activity; protein amino acid autophosphorylation; MAPKKK cascade |
| NCBI Summary: | This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q99759 |
| NCBI GenInfo Identifier: | 160332306 |
| NCBI Gene ID: | 4215 |
| NCBI Accession: | Q99759.2 |
| UniProt Secondary Accession: | Q99759,Q5BKZ6, Q8N3I9, B2RCW2, D3DU15, |
| UniProt Related Accession: | Q99759 |
| Molecular Weight: | 74,089 Da |
| NCBI Full Name: | Mitogen-activated protein kinase kinase kinase 3 |
| NCBI Synonym Full Names: | mitogen-activated protein kinase kinase kinase 3 |
| NCBI Official Symbol: | MAP3K3 |
| NCBI Official Synonym Symbols: | MEKK3; MAPKKK3 |
| NCBI Protein Information: | mitogen-activated protein kinase kinase kinase 3; MEKK 3; MEK kinase 3; MAP/ERK kinase kinase 3; MAPK/ERK kinase kinase 3 |
| UniProt Protein Name: | Mitogen-activated protein kinase kinase kinase 3 |
| UniProt Synonym Protein Names: | MAPK/ERK kinase kinase 3; MEK kinase 3; MEKK 3 |
| UniProt Gene Name: | MAP3K3 |
| UniProt Entry Name: | M3K3_HUMAN |