| UniProt Protein Function: | Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. |
| NCBI Summary: | The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P46734 |
| NCBI GenInfo Identifier: | 24638466 |
| NCBI Gene ID: | 5606 |
| NCBI Accession: | P46734.2 |
| UniProt Secondary Accession: | P46734,Q99441, Q9UE71, Q9UE72, B3KSK7, |
| UniProt Related Accession: | P46734 |
| Molecular Weight: | 39,940 Da |
| NCBI Full Name: | Dual specificity mitogen-activated protein kinase kinase 3 |
| NCBI Synonym Full Names: | mitogen-activated protein kinase kinase 3 |
| NCBI Official Symbol: | MAP2K3 |
| NCBI Official Synonym Symbols: | MEK3; MKK3; MAPKK3; PRKMK3; SAPKK2; SAPKK-2 |
| NCBI Protein Information: | dual specificity mitogen-activated protein kinase kinase 3 |
| UniProt Protein Name: | Dual specificity mitogen-activated protein kinase kinase 3 |
| UniProt Synonym Protein Names: | MAPK/ERK kinase 3; MEK 3; Stress-activated protein kinase kinase 2; SAPK kinase 2; SAPKK-2; SAPKK2 |
| Protein Family: | Dual specificity mitogen-activated protein kinase kinase |
| UniProt Gene Name: | MAP2K3 |
