Anti-MEIS1 Antibody (CAB18273)
- SKU:
- CAB18273
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
| 抗体名: | Anti-MEIS1 Antibody |
| 抗体コード: | CAB18273 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide of human MEIS1. |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | 293T, HeLa, K-562, HepG2, Mouse pancreas, Rat brain |
| 免疫原: | A synthetic peptide of human MEIS1. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 4211 |
| Uniprot: | O00470 |
| セルラーロケーション: | |
| 計算された分子量: | 43kDa |
| 観察された分子量: | 50kDa/55kDa |
 | Western blot - MEIS1 Rabbit pAb (CAB18273) |
| 同義語: | MEIS1 |
| バックグラウンド: | Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. |
| UniProt Protein Function: | MEIS1: Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias. Defects in MEIS1 could be a cause of susceptibility to restless legs syndrome type 7 (RLS7). Restless legs syndrome (RLS) is a neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation. Belongs to the TALE/MEIS homeobox family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 2p14 Molecular Function:protein binding Biological Process: negative regulation of myeloid cell differentiation Disease: Restless Legs Syndrome, Susceptibility To, 7 |
| NCBI Summary: | Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O00470 |
| NCBI GenInfo Identifier: | 3024112 |
| NCBI Gene ID: | 4211 |
| NCBI Accession: | O00470.1 |
| UniProt Secondary Accession: | O00470,A8MV50, |
| UniProt Related Accession: | O00470 |
| Molecular Weight: | 50,576 Da |
| NCBI Full Name: | Homeobox protein Meis1 |
| NCBI Synonym Full Names: | Meis homeobox 1 |
| NCBI Official Symbol: | MEIS1 |
| NCBI Protein Information: | homeobox protein Meis1 |
| UniProt Protein Name: | Homeobox protein Meis1 |
| Protein Family: | Homeobox protein |
| UniProt Gene Name: | MEIS1 |