Anti-MCU Antibody (CAB16281)

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SKU:
CAB16281
Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
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Description

system_update_altデータシートsystem_update_alt安全性データシート
抗体名:Anti-MCU Antibody
抗体コード:CAB16281
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB IF
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 1-351 of human MCU (NP_612366.1).
申し込み:WB IF
推奨希釈:WB 1:500 - 1:2000 IF 1:50 - 1:200
反応性:Human, Mouse, Rat
ポジティブサンプル:HepG2
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 1-351 of human MCU (NP_612366.1).
精製方法:Affinity purification
ストレージバッファ:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:MAAA AGRS LLLL LSSR GGGG GGAG GCGA LTAG CFPG LGVS RHRQ QQHH RTVH QRIA SWQN LGAV YCST VVPS DDVT VVYQ NGLP VISV RLPS RRER CQFT LKPI SDSV GVFL RQLQ EEDR GIDR VAIY SPDG VRVA ASTG IDLL LLDD FKLV INDL TYHV RPPK RDLL SHEN AATL NDVK TLVQ QLYT TLCI EQHQ LNKE RELI ERLE DLKE QLAP LEKV RIEI SRKA EKRT TLVL WGGL AYMA TQFG ILAR LTWW EYSW DIME PVTY FITY GSAM AMYA YFVM TRQE YVYP EARD RQYL LFFH KGAK KSRF DLEK YNQL KDAI AQAE MDLK RLRD PLQV HLPL RQIG EKD
遺伝子ID:90550
Uniprot:Q8NE86
セルラーロケーション:
計算された分子量:35kDa/36kDa/39kDa
観察された分子量:26KDa
同義語:MCU, C10orf42, CCDC109A, HsMCU
バックグラウンド:This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:MCU: Mitochondrial inner membrane calcium transporter that mediates calcium uptake into mitochondrion. Belongs to the MCU family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Mitochondrial; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 10q22.1

Cellular Component: integral to mitochondrial inner membrane; mitochondrial inner membrane; mitochondrion

Molecular Function:calcium channel activity; identical protein binding; protein binding; uniporter activity

Biological Process: calcium-mediated signaling; elevation of mitochondrial calcium ion concentration; glucose homeostasis; mitochondrial calcium ion transport; positive regulation of insulin secretion

NCBI Summary:This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
UniProt Code:Q8NE86
NCBI GenInfo Identifier:398303803
NCBI Gene ID:90550
NCBI Accession:NP_001257608.1
UniProt Secondary Accession:Q8NE86,Q96FL3, B2RDF3, B3KXV7,
UniProt Related Accession:Q8NE86
Molecular Weight:35,159 Da
NCBI Full Name:calcium uniporter protein, mitochondrial isoform 2
NCBI Synonym Full Names:mitochondrial calcium uniporter
NCBI Official Symbol:MCU  
NCBI Official Synonym Symbols:C10orf42; CCDC109A  
NCBI Protein Information:calcium uniporter protein, mitochondrial
UniProt Protein Name:Calcium uniporter protein, mitochondrial
UniProt Synonym Protein Names:Coiled-coil domain-containing protein 109A
Protein Family:Calcium uniporter protein
UniProt Gene Name:MCU  
UniProt Entry Name:MCU_HUMAN
Anti-MCU Antibody (CAB16281)Western blot analysis of extracts of HepG2 cells, using MCU Rabbit pAb (CAB16281) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 180s.
Anti-MCU Antibody (CAB16281)Immunofluorescence analysis of L929 cells using MCU antibody (CAB16281) at dilution of 1:100. Blue: DAPI for nuclear staining.
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