Anti-MCTS1 Antibody (CAB9061)
- SKU:
- CAB9061
- Product type:
- Antibody
- Application:
- WB
- Application:
- IF
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Frequently bought together:
Description
| 抗体名: | Anti-MCTS1 Antibody |
| 抗体コード: | CAB9061 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-181 of human MCTS1 (NP_054779.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | U-87MG, 293T |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-181 of human MCTS1 (NP_054779.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MFKK FDEK ENVS NCIQ LKTS VIKG IKNQ LIEQ FPGI EPWL NQIM PKKD PVKI VRCH EHIE ILTV NGEL LFFR QREG PFYP TLRL LHKY PFIL PHQQ VDKG AIKF VLSG ANIM CPGL TSPG AKLY PAAV DTIV AIMA EGKQ HALC VGVM KMSA EDIE KVNK GIGI ENIH YLND GLWH MKTY K |
| 遺伝子ID: | 28985 |
| Uniprot: | Q9ULC4 |
| セルラーロケーション: | Cytoplasm |
| 計算された分子量: | 19kDa/20kDa |
| 観察された分子量: | 20kDa |
| 同義語: | MCTS1, MCT-1, MCT1 |
| バックグラウンド: |
| UniProt Protein Function: | MCTS1: Anti-oncogene that play a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Plays a role as translation enhancer; Recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; Up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma- irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3. Belongs to the MCTS1 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Tumor suppressor Chromosomal Location of Human Ortholog: Xq24 Cellular Component: cytoplasm; plasma membrane Biological Process: formation of translation preinitiation complex; positive regulation of cell proliferation; ribosome disassembly |
| UniProt Code: | Q9ULC4 |
| NCBI GenInfo Identifier: | 74735052 |
| NCBI Gene ID: | 28985 |
| NCBI Accession: | Q9ULC4.1 |
| UniProt Secondary Accession: | Q9ULC4,Q502X6, B4DGY2, |
| UniProt Related Accession: | Q9ULC4 |
| Molecular Weight: | 20,550 Da |
| NCBI Full Name: | Malignant T-cell-amplified sequence 1 |
| NCBI Synonym Full Names: | MCTS1, re-initiation and release factor |
| NCBI Official Symbol: | MCTS1 |
| NCBI Official Synonym Symbols: | MCT1; MCT-1 |
| NCBI Protein Information: | malignant T-cell-amplified sequence 1 |
| UniProt Protein Name: | Malignant T-cell-amplified sequence 1 |
| UniProt Synonym Protein Names: | Multiple copies T-cell malignancies |
| Protein Family: | Malignant T-cell-amplified sequence |
| UniProt Gene Name: | MCTS1 |
| UniProt Entry Name: | MCTS1_HUMAN |
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