Anti-MCMBP Antibody (CAB3017)
- SKU:
- CAB3017
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Frequently bought together:
Description
| 抗体名: | Anti-MCMBP Antibody |
| 抗体コード: | CAB3017 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human MCMBP (NP_079110.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | A-431, Mouse spleen, Mouse liver, Mouse ovary |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human MCMBP (NP_079110.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MPCG EDWL SHPL GIVQ GFFA QNGV NPDW EKKV IEYF KEKL KENN APKW VPSL NEVP LHYL KPNS FVKF RCMI QDMF DPEF YMGV YETV NQNT KAHV LHFG KYRD VAEC GPQQ ELDL NSPR NTTL ERQT FYCV PVPG ESTW VKEA YVNA NQAR VSPS TSYT PSRH KRSY EDDD DMDL QPNK QKDQ HAGA RQAG SVGG LQWC GEPK RLET EAST GQQL NSLN LSSP FDLN FPLP GEKG PACL |
| 遺伝子ID: | 79892 |
| Uniprot: | Q9BTE3 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 52kDa/72kDa |
| 観察された分子量: | 73kDa |
| 同義語: | MCMBP, C10orf119, MCM-BP |
| バックグラウンド: | This gene encodes a protein which is a component of the hexameric minichromosome maintenance (MCM) complex which regulates initiation and elongation of DNA. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | MCMBP: Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion. Belongs to the MCMBP family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 10q26.11 Cellular Component: nucleoplasm; MCM complex; cytoplasm; plasma membrane; nucleus Molecular Function:protein binding; chromatin binding Biological Process: mitosis; cell division; sister chromatid cohesion; DNA-dependent DNA replication |
| NCBI Summary: | This gene encodes a protein which is a component of the hexameric minichromosome maintenance (MCM) complex which regulates initiation and elongation of DNA. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] |
| UniProt Code: | Q9BTE3 |
| NCBI GenInfo Identifier: | 71153001 |
| NCBI Gene ID: | 79892 |
| NCBI Accession: | Q9BTE3.2 |
| UniProt Related Accession: | Q9BTE3 |
| Molecular Weight: | 52kDa; 72kDa |
| NCBI Full Name: | Mini-chromosome maintenance complex-binding protein |
| NCBI Synonym Full Names: | minichromosome maintenance complex binding protein |
| NCBI Official Symbol: | MCMBP |
| NCBI Official Synonym Symbols: | MCM-BP; C10orf119 |
| NCBI Protein Information: | mini-chromosome maintenance complex-binding protein |
| UniProt Protein Name: | Mini-chromosome maintenance complex-binding protein |
| Protein Family: | Mini-chromosome maintenance complex-binding protein |
| UniProt Gene Name: | MCMBP |
| UniProt Entry Name: | MCMBP_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MCMBP antibody (CAB3017) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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