Anti-MCF2L Antibody (CAB9966)
- SKU:
- CAB9966
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-MCF2L Antibody |
抗体コード: | CAB9966 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 850-980 of human MCF2L (NP_079255.4). |
申し込み: | WB |
推奨希釈: | WB 1:1000 - 1:4000 |
反応性: | Human, Mouse |
ポジティブサンプル: | MCF7, Mouse heart, Mouse kidney, Mouse lung |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 850-980 of human MCF2L (NP_079255.4). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | YEKA PSYS YKQS LNMA AVGI TENV KGDA KKFE IWYN AREE VYIV QAPT PEIK AAWV NEIR KVLT SQLQ ACRE ASQH RALE QSQS LPLP APTS TSPS RGNS RNIK KLEE RKTD PLSL EGYV SSAP LTKP PEK |
遺伝子ID: | 23263 |
Uniprot: | O15068 |
セルラーロケーション: | Cell membrane, Cytoplasm, Cytoplasmic side, Peripheral membrane protein |
計算された分子量: | 102-128kDa |
観察された分子量: | 128kDa |
同義語: | MCF2L, ARHGEF14, DBS, OST |
バックグラウンド: | This gene encodes a guanine nucleotide exchange factor that interacts specifically with the GTP-bound Rac1 and plays a role in the Rho/Rac signaling pathways. A variant in this gene was associated with osteoarthritis. Alternative splicing results in multiple transcript variants. |
UniProt Protein Function: | ARHGEF14: Guanine nucleotide exchange factor that potentially links pathways that signal through RAC1, RHOA and CDC42. Catalyzes guanine nucleotide exchange on RHOA and CDC42 and interacts specifically with the GTP-bound form of RAC1, suggesting that it functions as an effector of RAC1. May also participate in axonal transport in the brain. Becomes activated and highly tumorigenic by truncation of the N-terminus. Isoform 5 activates CDC42. Belongs to the MCF2 family. 8 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:GEFs, Rac/Rho; GEFs; Oncoprotein Chromosomal Location of Human Ortholog: 13q34 Cellular Component: cytosol; extracellular space Molecular Function:guanyl-nucleotide exchange factor activity; phosphoinositide binding; Rho guanyl-nucleotide exchange factor activity Biological Process: positive regulation of apoptosis; regulation of small GTPase mediated signal transduction |
NCBI Summary: | This gene encodes a guanine nucleotide exchange factor that interacts specifically with the GTP-bound Rac1 and plays a role in the Rho/Rac signaling pathways. A variant in this gene was associated with osteoarthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] |
UniProt Code: | O15068 |
NCBI GenInfo Identifier: | 148887400 |
NCBI Gene ID: | 23263 |
NCBI Accession: | O15068.2 |
UniProt Secondary Accession: | O15068,Q5JU56, Q5VXT1, Q6ZWD4, Q765G8, A2A2X1, A2A2X2 A2A3G6, A2A3G8, B4DHD6, B4DIL6, E9PDN8, |
UniProt Related Accession: | O15068 |
Molecular Weight: | 126,111 Da |
NCBI Full Name: | Guanine nucleotide exchange factor DBS |
NCBI Synonym Full Names: | MCF.2 cell line derived transforming sequence like |
NCBI Official Symbol: | MCF2L |
NCBI Official Synonym Symbols: | DBS; OST; ARHGEF14 |
NCBI Protein Information: | guanine nucleotide exchange factor DBS |
UniProt Protein Name: | Guanine nucleotide exchange factor DBS |
UniProt Synonym Protein Names: | DBL's big sister; MCF2-transforming sequence-like protein |
Protein Family: | Guanine nucleotide exchange factor |
UniProt Gene Name: | MCF2L |
UniProt Entry Name: | MCF2L_HUMAN |
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