Anti-MC3R Antibody (CAB3011)
- SKU:
- CAB3011
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| 抗体名: | Anti-MC3R Antibody |
| 抗体コード: | CAB3011 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide of human MC3R |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | Mouse large intestine |
| 免疫原: | A synthetic peptide of human MC3R |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 4159 |
| Uniprot: | P41968 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 36kDa |
| 観察された分子量: | 36kDa |
| 同義語: | MC3R, BMIQ9, MC3, MC3-R, OB20, OQTL |
| バックグラウンド: | This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans. |
| UniProt Protein Function: | MC3R: Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1 Chromosomal Location of Human Ortholog: 20q13.2-q13.3 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:neuropeptide binding; protein binding; melanocortin receptor activity; peptide hormone binding; melanocyte stimulating hormone receptor activity Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to cyclic nucleotide second messenger; regulation of heart rate; homoiothermy; regulation of blood pressure; positive regulation of cAMP biosynthetic process; sodium ion homeostasis; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); circadian regulation of gene expression Disease: Body Mass Index Quantitative Trait Locus 9; Mycobacterium Tuberculosis, Susceptibility To |
| NCBI Summary: | This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P41968 |
| NCBI GenInfo Identifier: | 395398606 |
| NCBI Gene ID: | 4159 |
| NCBI Accession: | P41968.3 |
| UniProt Related Accession: | P41968 |
| Molecular Weight: | |
| NCBI Full Name: | Melanocortin receptor 3 |
| NCBI Synonym Full Names: | melanocortin 3 receptor |
| NCBI Official Symbol: | MC3R |
| NCBI Official Synonym Symbols: | MC3; OB20; OQTL; BMIQ9; MC3-R |
| NCBI Protein Information: | melanocortin receptor 3 |
| UniProt Protein Name: | Melanocortin receptor 3 |
| Protein Family: | Melanocortin receptor |
| UniProt Gene Name: | MC3R |
| UniProt Entry Name: | MC3R_HUMAN |
 | Western blot analysis of extracts of mouse large intestine, using MC3R antibody (CAB3011). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |