Anti-MC2R Antibody (CAB3010)
- SKU:
- CAB3010
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-MC2R Antibody |
| 抗体コード: | CAB3010 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human MC2R |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:1000 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | Raji, Mouse kidney |
| 免疫原: | Recombinant protein of human MC2R |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 4158 |
| Uniprot: | Q01718 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 33kDa |
| 観察された分子量: | 37kDa |
| 同義語: | MC2R, ACTHR |
| バックグラウンド: | MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Alternate transcript variants have been found for this gene. |
| UniProt Protein Function: | MC2R: Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase. Defects in MC2R are the cause of glucocorticoid deficiency type 1 (GCCD1); also known as familial glucocorticoid deficiency type 1 (FGD1). GCCD1 is an autosomal recessive disorder due to congenital insensitivity or resistance to adrenocorticotropin (ACTH). It is characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 18p11.2 Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane Molecular Function:protein binding; melanocortin receptor activity; adrenocorticotropin receptor activity Biological Process: G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cyclic nucleotide second messenger; neuropeptide signaling pathway; positive regulation of cAMP biosynthetic process; placenta development Disease: Glucocorticoid Deficiency 1 |
| NCBI Summary: | MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Alternate transcript variants have been found for this gene. [provided by RefSeq, May 2014] |
| UniProt Code: | Q01718 |
| NCBI GenInfo Identifier: | 399002 |
| NCBI Gene ID: | 4158 |
| NCBI Accession: | Q01718.1 |
| UniProt Secondary Accession: | Q01718,Q3MI45, Q504X6, A8K016, |
| UniProt Related Accession: | Q01718 |
| Molecular Weight: | 297 |
| NCBI Full Name: | Adrenocorticotropic hormone receptor |
| NCBI Synonym Full Names: | melanocortin 2 receptor (adrenocorticotropic hormone) |
| NCBI Official Symbol: | MC2R |
| NCBI Official Synonym Symbols: | ACTHR |
| NCBI Protein Information: | adrenocorticotropic hormone receptor; MC2 receptor; ACTH receptor; corticotropin receptor; adrenocorticotropin receptor |
| UniProt Protein Name: | Adrenocorticotropic hormone receptor |
| UniProt Synonym Protein Names: | Adrenocorticotropin receptor; Melanocortin receptor 2; MC2-R |
| Protein Family: | Adrenocorticotropic hormone receptor |
| UniProt Gene Name: | MC2R |
| UniProt Entry Name: | ACTHR_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MC2R antibody (CAB3010) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
View AllClose