Anti-MARCH6 Antibody (CAB16097)

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SKU:
CAB16097
Product type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction
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Description

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抗体名:Anti-MARCH6 Antibody
抗体コード:CAB16097
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB
反応性:Human
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 10-80 of human MARCH6 (NP_005876.2).
申し込み:WB
推奨希釈:WB 1:500 - 1:2000
反応性:Human
ポジティブサンプル:293T, HepG2
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 10-80 of human MARCH6 (NP_005876.2).
精製方法:Affinity purification
ストレージバッファ:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:RVCR SEGT PEKP LYHP CVCT GSIK FIHQ ECLV QWLK HSRK EYCE LCKH RFAF TPIY SPDM PSRL PIQD IFA
遺伝子ID:10299
Uniprot:O60337
セルラーロケーション:Endoplasmic reticulum membrane, Multi-pass membrane protein
計算された分子量:90kDa/97kDa/102kDa
観察された分子量:102kDa
同義語:MARCH6, DOA10, MARCH-VI, RNF176, TEB4
バックグラウンド:This gene encodes a member of a family of membrane-associated E3 ubiquitin ligases containing RING-CH-type zinc finger motifs. Ubiquitination of type II deiodinase by the encoded protein is an important regulatory step in thyroid hormone signalling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
UniProt Protein Function:MARCH6: E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1.
UniProt Protein Details:

Protein type:EC 6.3.2.-; EC 6.3.2.19; Ligase; Membrane protein, integral; Membrane protein, multi-pass; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 5p15.2

Cellular Component: integral to endoplasmic reticulum membrane; integral to membrane; membrane

Molecular Function:enzyme binding; ubiquitin conjugating enzyme binding; ubiquitin-protein ligase activity

Biological Process: ER-associated protein catabolic process; proteasomal protein catabolic process

NCBI Summary:This gene encodes a member of a family of membrane-associated E3 ubiquitin ligases containing RING-CH-type zinc finger motifs. Ubiquitination of type II deiodinase by the encoded protein is an important regulatory step in thyroid hormone signalling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
UniProt Code:O60337
NCBI GenInfo Identifier:2331104
NCBI Gene ID:10299
NCBI Accession:AAB66840.1
UniProt Secondary Accession:O60337,O14670, Q86X77, A5PKZ4, B4DKJ2, B4DT33, D3DTC8
UniProt Related Accession:O60337
Molecular Weight:90,413 Da
NCBI Full Name:TEB4 protein
NCBI Synonym Full Names:membrane associated ring-CH-type finger 6
NCBI Official Symbol:MARCH6  
NCBI Official Synonym Symbols:TEB4; DOA10; RNF176; MARCH-VI  
NCBI Protein Information:E3 ubiquitin-protein ligase MARCH6
UniProt Protein Name:E3 ubiquitin-protein ligase MARCH6
UniProt Synonym Protein Names:Doa10 homolog; Membrane-associated RING finger protein 6; Membrane-associated RING-CH protein VI; MARCH-VI; Protein TEB-4; RING finger protein 176; RING-type E3 ubiquitin transferase MARCH6Curated
UniProt Gene Name:MARCH6  
Anti-MARCH6 Antibody (CAB16097)Western blot analysis of extracts of various cell lines, using MARCH6 Rabbit pAb (CAB16097) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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