Anti-MAPKBP1 Antibody (CAB12576)
- SKU:
- CAB12576
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-MAPKBP1 Antibody |
抗体コード: | CAB12576 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MAPKBP1 (NP_001122080.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse |
ポジティブサンプル: | U-87MG, Mouse liver, Mouse lung |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MAPKBP1 (NP_001122080.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MAVE GSTI TSRI KNLL RSPS IKLR RSKA GNRR EDLS SKVT LEKV LGIT VSGG RGLA CDPR SGLV AYPA GCVV VLFN PRKH KQHH ILNS SRKT ITAL AFSP |
遺伝子ID: | 23005 |
Uniprot: | O60336 |
セルラーロケーション: | |
計算された分子量: | 23kDa/109kDa/134kDa/149kDa/163kDa |
観察された分子量: | 164kDa |
同義語: | MAPKBP1, JNKBP-1, JNKBP1, NPHP20 |
バックグラウンド: | This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients. |
UniProt Protein Function: | MAPKBP1: Involved in JNK signaling pathway. 6 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 15q15.1 |
UniProt Code: | O60336 |
NCBI GenInfo Identifier: | 215274254 |
NCBI Gene ID: | 23005 |
NCBI Accession: | O60336.4 |
UniProt Secondary Accession: | O60336,Q14CB5, Q14CD8, Q49AJ8, Q5W9G9, A6NM93, A8K8P9 |
UniProt Related Accession: | O60336 |
Molecular Weight: | Calculated MW: 23kDa/109kDa/134kDa/149kDa/163kDaObserved MW: 164kDa |
NCBI Full Name: | Mitogen-activated protein kinase-binding protein 1 |
NCBI Synonym Full Names: | mitogen-activated protein kinase binding protein 1 |
NCBI Official Symbol: | MAPKBP1 |
NCBI Official Synonym Symbols: | JNKBP-1 |
NCBI Protein Information: | mitogen-activated protein kinase-binding protein 1; JNK-binding protein 1; mitogen activated protein kinase binding protein 1 |
UniProt Protein Name: | Mitogen-activated protein kinase-binding protein 1 |
UniProt Synonym Protein Names: | JNK-binding protein 1; JNKBP-1 |
Protein Family: | Mitogen-activated protein kinase-binding protein |
UniProt Gene Name: | MAPKBP1 |
UniProt Entry Name: | MABP1_HUMAN |
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