Anti-MAPK8IP3 Antibody (CAB18426)
- SKU:
- CAB18426
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
| 抗体名: | Anti-MAPK8IP3 Antibody |
| 抗体コード: | CAB18426 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human MAPK8IP3. |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: |
| 免疫原: | Recombinant protein of human MAPK8IP3. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 23162 |
| Uniprot: | Q9UPT6 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | Refer to figures |
| 同義語: | JIP-3, JIP3, JSAP1, SYD2, syd, MAPK8IP3 |
| バックグラウンド: |
| UniProt Protein Function: | JIP3: a member of the JNK-interacting protein group of scaffold proteins that selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies in the mouse suggested that this protein may interact with and regulate the activity of numerous protein kinases of the JNK signaling pathway. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: Golgi membrane; smooth endoplasmic reticulum; dendrite; cytoplasm; axolemma Molecular Function:JUN kinase binding; MAP-kinase scaffold activity; receptor signaling complex scaffold activity; mitogen-activated protein kinase kinase binding; kinesin binding; mitogen-activated protein kinase kinase kinase binding Biological Process: vesicle-mediated transport; axon guidance; protein localization; regulation of gene expression; in utero embryonic development; forebrain development; respiratory gaseous exchange; positive regulation of neuron differentiation; regulation of JNK cascade; alveolus development; activation of JNK activity; post-embryonic development |
| NCBI Summary: | The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UPT6 |
| NCBI GenInfo Identifier: | 145559484 |
| NCBI Gene ID: | 23162 |
| NCBI Accession: | Q9UPT6.3 |
| UniProt Secondary Accession: | Q9UPT6,Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0, A2A2B3, A7E2B3 |
| UniProt Related Accession: | Q9UPT6 |
| Molecular Weight: | 29,052 Da |
| NCBI Full Name: | C-Jun-amino-terminal kinase-interacting protein 3 |
| NCBI Synonym Full Names: | mitogen-activated protein kinase 8 interacting protein 3 |
| NCBI Official Symbol: | MAPK8IP3 |
| NCBI Official Synonym Symbols: | syd; JIP3; SYD2; JSAP1 |
| NCBI Protein Information: | C-Jun-amino-terminal kinase-interacting protein 3; JIP-3; JNK-interacting protein 3; JNK/SAPK-associated protein-1; JNK MAP kinase scaffold protein 3; homolog of Drosophila Sunday driver 2; C-jun-amino-terminal kinase interacting protein 3; JNK/stress-activated protein kinase-associated protein 1; mitogen-activated protein kinase 8-interacting protein 3 |
| UniProt Protein Name: | C-Jun-amino-terminal kinase-interacting protein 3 |
| UniProt Synonym Protein Names: | JNK MAP kinase scaffold protein 3; Mitogen-activated protein kinase 8-interacting protein 3 |
| Protein Family: | C-Jun-amino-terminal kinase-interacting protein |
| UniProt Gene Name: | MAPK8IP3 |
| UniProt Entry Name: | JIP3_HUMAN |