Anti-MAML2 Antibody (CAB17225)
- SKU:
- CAB17225
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-MAML2 Antibody |
| 抗体コード: | CAB17225 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 750-850 of human MAML2 (NP_115803.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | A-549, 293T, Mouse brain, Mouse lung |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 750-850 of human MAML2 (NP_115803.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | NQQL MGKK QTLQ RQIM EQKQ QLLL QQQM LADA EKIA PQDQ INRH LSRP PPDY KDQR RNVG NMQP TAQY SGGS STIS LNSN QALA NPVS THTI LTPN SSLL S |
| 遺伝子ID: | 84441 |
| Uniprot: | Q8IZL2 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | 150kDa |
 | Western blot - MAML2 Rabbit pAb (CAB17225) |
| 同義語: | MAML2, MAM-3, MAM2, MAM3, MLL-MAML2 |
| バックグラウンド: | The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the polyglutamine tract has been observed. |
| UniProt Protein Function: | MAML2: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3. Interacts through its N-terminal region with the ankyrin repeat region of the Notch proteins NOTCH1, NOTCH2, NOTCH3 and NOTCH4. Forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa. Widely expressed with high levels detected in placenta, salivary gland and skeletal muscle. Belongs to the mastermind family. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 11q21 Cellular Component: Golgi apparatus; nucleoplasm; nucleus Molecular Function:transcription coactivator activity Biological Process: activation of Notch receptor target transcription factor; Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter |
| NCBI Summary: | The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the polyglutamine tract has been observed. [provided by RefSeq, Jan 2015] |
| UniProt Code: | Q8IZL2 |
| NCBI GenInfo Identifier: | 296435513 |
| NCBI Gene ID: | 84441 |
| NCBI Accession: | Q8IZL2.2 |
| UniProt Secondary Accession: | Q8IZL2,Q6AI23, Q6Y3A3, Q8IUL3, Q96JK6, A7MD26, |
| UniProt Related Accession: | Q8IZL2 |
| Molecular Weight: | 125,197 Da |
| NCBI Full Name: | Mastermind-like protein 2 |
| NCBI Synonym Full Names: | mastermind like transcriptional coactivator 2 |
| NCBI Official Symbol: | MAML2 |
| NCBI Official Synonym Symbols: | MAM2; MAM3; MAM-3; MLL-MAML2 |
| NCBI Protein Information: | mastermind-like protein 2 |
| UniProt Protein Name: | Mastermind-like protein 2 |
| Protein Family: | Mastermind-like protein |
| UniProt Gene Name: | MAML2 |
| UniProt Entry Name: | MAML2_HUMAN |