Anti-MAGOH Antibody (CAB3579)

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SKU:
CAB3579
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
MAGOH1
Synonyms:
MAGOHA
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Description

I抗体名:MAGOH Rabbit mAb
抗体コード:CAB3579
サイズ:20uL, 50uL, 100uL
同義語:MAGOH1, MAGOHA
申し込み:WB
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:A synthesized peptide derived from human MAGOH
申し込み:WB
推奨される希釈:WB 1:500 - 1:2000
反応性:Human, Mouse, Rat
ポジティブサンプル:HeLa, A-549, Jurkat, Mouse spleen, Rat thymus, Rat lung, Rat spleen
免疫原:A synthesized peptide derived from human MAGOH
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:4116
Uniprot:P61326
計算された分子量:17kDa
観察された分子量:17KDa
UniProt Protein Function:MAGOH: Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mRNA and thereby influences downstream processes of gene expression including mRNA splicing, nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Remains associated with the mRNA after its export to the cytoplasm and require translation of the mRNA for removal. The heterodimer MAGOH-RBM8A interacts with PYM that function to enhance the translation of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Belongs to the mago nashi family.
UniProt Protein Details:

Protein type:RNA splicing; Spliceosome

Chromosomal Location of Human Ortholog: 1p32.3

Cellular Component: nucleoplasm; nuclear speck; nucleus; cytosol

Molecular Function:protein binding

Biological Process: regulation of translation; transcription from RNA polymerase II promoter; nuclear mRNA splicing, via spliceosome; mRNA export from nucleus; RNA splicing; mRNA catabolic process, nonsense-mediated decay; gene expression; mRNA 3'-end processing; termination of RNA polymerase II transcription; regulation of alternative nuclear mRNA splicing, via spliceosome

NCBI Summary:Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts. [provided by RefSeq, Jul 2008]
UniProt Code:P61326
NCBI GenInfo Identifier:47117708
NCBI Gene ID:4116
NCBI Accession:P61326.1
UniProt Secondary Accession:P61326,O35169, P50606, Q5SW69, B1ARP8, B2R5A2,
UniProt Related Accession:P61326
Molecular Weight:146
NCBI Full Name:Protein mago nashi homolog
NCBI Synonym Full Names:mago-nashi homolog, proliferation-associated (Drosophila)
NCBI Official Symbol:MAGOH  
NCBI Official Synonym Symbols:MAGOH1; MAGOHA  
NCBI Protein Information:protein mago nashi homolog
UniProt Protein Name:Protein mago nashi homolog
Protein Family:Protein mago nashi
UniProt Gene Name:MAGOH  
UniProt Entry Name:MGN_HUMAN
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