Anti-MAGED1 Antibody (CAB1092)
- SKU:
- CAB1092
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-MAGED1 Antibody |
| 抗体コード: | CAB1092 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 635-834 of human MAGED1 (NP_001005333.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Mouse liver, Mouse lung, Rat lung, Rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 635-834 of human MAGED1 (NP_001005333.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | EAVL WEAL RKMG LRPG VRHP LLGD LRKL LTYE FVKQ KYLD YRRV PNSN PPEY EFLW GLRS YHET SKMK VLRF IAEV QKRD PRDW TAQF MEAA DEAL DALD AAAA EAEA RAEA RTRM GIGD EAVS GPWS WDDI EFEL LTWD EEGD FGDP WSRI PFTF WARY HQNA RSRF PQTF AGPI IGPG GTAS ANFA ANFG AIGF FWVE |
| 遺伝子ID: | 9500 |
| Uniprot: | Q9Y5V3 |
| セルラーロケーション: | Cell membrane, Cytoplasm, Nucleus, Peripheral membrane protein |
| 計算された分子量: | 86kDa/91kDa |
| 観察された分子量: | 86kDa |
| 同義語: | MAGED1, DLXIN-1, NRAGE |
| バックグラウンド: | This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene. |
| UniProt Protein Function: | NRAGE: a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although NRAGE shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. Binds p75 neurotrophin receptor (p75NTR) and antagonizes its association with TrkA, inhibits cell cycle progression, and facilitates p75NTR-mediated apoptosis. May act as a regulator of the function of DLX family members. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: Xp11.23 Cellular Component: protein complex; cytoplasm; plasma membrane; chromatin; nucleus Molecular Function:protein binding; transcription coactivator activity Biological Process: regulation of apoptosis; regulation of transcription from RNA polymerase II promoter; positive regulation of MAP kinase activity; regulation of transcription, DNA-dependent; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; circadian regulation of gene expression; regulation of circadian rhythm; negative regulation of transcription, DNA-dependent; negative regulation of epithelial cell proliferation |
| NCBI Summary: | This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y5V3 |
| NCBI GenInfo Identifier: | 62906893 |
| NCBI Gene ID: | 9500 |
| NCBI Accession: | Q9Y5V3.3 |
| UniProt Related Accession: | Q9Y5V3 |
| Molecular Weight: | |
| NCBI Full Name: | Melanoma-associated antigen D1 |
| NCBI Synonym Full Names: | MAGE family member D1 |
| NCBI Official Symbol: | MAGED1 |
| NCBI Official Synonym Symbols: | NRAGE; DLXIN-1 |
| NCBI Protein Information: | melanoma-associated antigen D1 |
| UniProt Protein Name: | Melanoma-associated antigen D1 |
| UniProt Synonym Protein Names: | MAGE tumor antigen CCF; MAGE-D1 antigen; Neurotrophin receptor-interacting MAGE homolog |
| UniProt Gene Name: | MAGED1 |
| UniProt Entry Name: | MAGD1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MAGED1 antibody (CAB1092) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human liver cancer using MAGED1 antibody (CAB1092) at dilution of 1:100 (40x lens). |
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