Anti-MAGEA1 Antibody (CAB5470)
- SKU:
- CAB5470
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-MAGEA1 Antibody |
抗体コード: | CAB5470 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-309 of human MAGEA1 (NP_004979.3). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 |
反応性: | Human |
ポジティブサンプル: | 22Rv1 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-309 of human MAGEA1 (NP_004979.3). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MSLE QRSL HCKP EEAL EAQQ EALG LVCV QAAT SSSS PLVL GTLE EVPT AGST DPPQ SPQG ASAF PTTI NFTR QRQP SEGS SSRE EEGP STSC ILES LFRA VITK KVAD LVGF LLLK YRAR EPVT KAEM LESV IKNY KHCF PEIF GKAS ESLQ LVFG IDVK EADP TGHS YVLV TCLG LSYD GLLG DNQI MPKT GFLI IVLV MIAM EGGH APEE EIWE ELSV MEVY DGRE HSAY GEPR KLLT QDLV QEKY LEYR QVPD SDPA RYEF LWGP RALA ETSY VKVL EYVI KVSA RVRF FFPS LREA ALRE EEEG V |
遺伝子ID: | 4100 |
Uniprot: | P43355 |
セルラーロケーション: | Cytoplasm, Nucleus |
計算された分子量: | 34kDa |
観察された分子量: | 45kDa |
同義語: | MAGEA1, CT1.1, MAGE1 |
バックグラウンド: | This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. |
UniProt Protein Function: | MAGE-A1: a tumor antigen expressed in a variety of tumor cells and in the testis. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. |
UniProt Protein Details: | Protein type:Cell surface Chromosomal Location of Human Ortholog: Xq28 Cellular Component: cytoplasm; plasma membrane; nucleus Molecular Function:protein binding; histone deacetylase binding Biological Process: transcription, DNA-dependent; negative regulation of Notch signaling pathway; negative regulation of transcription from RNA polymerase II promoter |
NCBI Summary: | This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008] |
UniProt Code: | P43355 |
NCBI GenInfo Identifier: | 1170855 |
NCBI Gene ID: | 4100 |
NCBI Accession: | P43355.1 |
UniProt Secondary Accession: | P43355,O00346, B2RC81, |
UniProt Related Accession: | P43355,AAB33086 |
Molecular Weight: | 309 |
NCBI Full Name: | Melanoma-associated antigen 1 |
NCBI Synonym Full Names: | melanoma antigen family A, 1 (directs expression of antigen MZ2-E) |
NCBI Official Symbol: | MAGEA1 |
NCBI Official Synonym Symbols: | CT1.1; MAGE1 |
NCBI Protein Information: | melanoma-associated antigen 1; antigen MZ2-E; MAGE-1 antigen; melanoma antigen MAGE-1; cancer/testis antigen 1.1; melanoma antigen family A 1; melanoma-associated antigen MZ2-E; cancer/testis antigen family 1, member 1 |
UniProt Protein Name: | Melanoma-associated antigen 1 |
UniProt Synonym Protein Names: | Antigen MZ2-E; Cancer/testis antigen 1.1; CT1.1; MAGE-1 antigen |
Protein Family: | Melanoma-associated antigen |
UniProt Gene Name: | MAGEA1 |
UniProt Entry Name: | MAGA1_HUMAN |
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