Anti-MAG Antibody (CAB7186)
- SKU:
- CAB7186
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-MAG Antibody |
| 抗体コード: | CAB7186 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human MAG |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:3000 IF 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | SH-SY5Y, MCF7, K-562, SW620, Jurkat, Mouse brain, Rat brain |
| 免疫原: | Recombinant protein of human MAG |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 4099 |
| Uniprot: | P20916 |
| セルラーロケーション: | Membrane, Single-pass type I membrane protein |
| 計算された分子量: | 63kDa/66kDa/69kDa |
| 観察された分子量: | 120kDa |
| 同義語: | MAG, GMA, S-MAG, SIGLEC-4A, SIGLEC4A, SPG75 |
| バックグラウンド: | The protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. |
| UniProt Protein Function: | MAG: Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3- linked sialic acid. Binds to RTN4R. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.1 Cellular Component: paranode region of axon; plasma membrane; integral to membrane Molecular Function:carbohydrate binding Biological Process: substantia nigra development; nerve growth factor receptor signaling pathway; negative regulation of axonogenesis; regulation of axonogenesis; cell adhesion; blood coagulation; leukocyte migration |
| NCBI Summary: | The protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2010] |
| UniProt Code: | P20916 |
| NCBI GenInfo Identifier: | 126689 |
| NCBI Gene ID: | 4099 |
| NCBI Accession: | P20916.1 |
| UniProt Secondary Accession: | P20916,Q567S4, B7Z2E5, F5GYC0, |
| UniProt Related Accession: | P20916 |
| Molecular Weight: | 66,224 Da |
| NCBI Full Name: | Myelin-associated glycoprotein |
| NCBI Synonym Full Names: | myelin associated glycoprotein |
| NCBI Official Symbol: | MAG |
| NCBI Official Synonym Symbols: | GMA; S-MAG; SIGLEC4A; SIGLEC-4A |
| NCBI Protein Information: | myelin-associated glycoprotein; sialic acid binding Ig-like lectin 4A; sialic acid-binding immunoglobulin-like lectin 4A |
| UniProt Protein Name: | Myelin-associated glycoprotein |
| UniProt Synonym Protein Names: | Siglec-4a |
| Protein Family: | Magainins |
| UniProt Gene Name: | MAG |
| UniProt Entry Name: | MAG_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MAG antibody (CAB7186) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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