| UniProt Protein Function: | MADCAM1: Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L- selectin binding. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Membrane protein, integral Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: membrane; integral to membrane; plasma membrane Biological Process: integrin-mediated signaling pathway; regulation of immune response; extracellular matrix organization and biogenesis; positive regulation of leukocyte migration; cell-matrix adhesion; signal transduction; receptor clustering; keratinocyte differentiation; heterotypic cell-cell adhesion; immune response; leukocyte tethering or rolling; cell adhesion; aging |
| NCBI Summary: | The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13477 |
| NCBI GenInfo Identifier: | 218511712 |
| NCBI Gene ID: | 8174 |
| NCBI Accession: | Q13477.2 |
| UniProt Secondary Accession: | Q13477,O60222, O75867, Q5UGI7, A5PKV4, B2RPL9, |
| UniProt Related Accession: | Q13477 |
| Molecular Weight: | 382 |
| NCBI Full Name: | Mucosal addressin cell adhesion molecule 1 |
| NCBI Synonym Full Names: | mucosal vascular addressin cell adhesion molecule 1 |
| NCBI Official Symbol: | MADCAM1 |
| NCBI Official Synonym Symbols: | MACAM1 |
| NCBI Protein Information: | mucosal addressin cell adhesion molecule 1; MAdCAM-1; hMAdCAM-1; mucosal addressin cell adhesion molecule-1 |
| UniProt Protein Name: | Mucosal addressin cell adhesion molecule 1 |
| Protein Family: | Mucosal addressin cell adhesion molecule |
| UniProt Gene Name: | MADCAM1 |
| UniProt Entry Name: | MADCA_HUMAN |
