Anti-M6PR Antibody (CAB6296)
- SKU:
- CAB6296
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-M6PR Antibody |
| 抗体コード: | CAB6296 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-185 of human M6PR (NP_002346.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Mouse kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-185 of human M6PR (NP_002346.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | TEEK TCDL VGEK GKES EKEL ALVK RLKP LFNK SFES TVGQ GSDT YIYI FRVC REAG NHTS GAGL VQIN KSNG KETV VGRL NETH IFNG SNWI MLIY KGGD EYDN HCGK EQRR AVVM ISCN RHTL ADNF NPVS EERG KVQD CFYL FEMD SSLA CSPE ISH |
| 遺伝子ID: | 4074 |
| Uniprot: | P20645 |
| セルラーロケーション: | Lysosome membrane, Single-pass type I membrane protein |
| 計算された分子量: | 30kDa |
| 観察された分子量: | 31kDa |
| 同義語: | M6PR, CD-M6PR, CD-MPR, MPR 46, MPR-46, MPR46, SMPR |
| バックグラウンド: | This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. |
| UniProt Protein Function: | M6PR: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 12p13 Cellular Component: endosome; integral to plasma membrane; membrane; perinuclear region of cytoplasm; trans-Golgi network; trans-Golgi network membrane; transport vesicle Molecular Function:transmembrane receptor activity Biological Process: endosome to lysosome transport; receptor-mediated endocytosis |
| NCBI Summary: | This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011] |
| UniProt Code: | P20645 |
| NCBI GenInfo Identifier: | 127293 |
| NCBI Gene ID: | 4074 |
| NCBI Accession: | P20645.1 |
| UniProt Secondary Accession: | P20645,A8K528, D3DUV5, |
| UniProt Related Accession: | P20645 |
| Molecular Weight: | 30,993 Da |
| NCBI Full Name: | Cation-dependent mannose-6-phosphate receptor |
| NCBI Synonym Full Names: | mannose-6-phosphate receptor, cation dependent |
| NCBI Official Symbol: | M6PR |
| NCBI Official Synonym Symbols: | SMPR; MPR46; CD-MPR; MPR 46; MPR-46; CD-M6PR |
| NCBI Protein Information: | cation-dependent mannose-6-phosphate receptor |
| UniProt Protein Name: | Cation-dependent mannose-6-phosphate receptor |
| UniProt Synonym Protein Names: | 46 kDa mannose 6-phosphate receptor; MPR 46 |
| Protein Family: | Cation-dependent mannose-6-phosphate receptor |
| UniProt Gene Name: | M6PR |
| UniProt Entry Name: | MPRD_HUMAN |
 | Western blot analysis of extracts of mouse kidney, using M6PR antibody (CAB6296) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 40s. |
 | Immunohistochemistry of paraffin-embedded human liver damage using M6PR antibody (CAB6296) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using M6PR antibody (CAB6296) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse heart using M6PR antibody (CAB6296) at dilution of 1:100 (40x lens). |
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