Anti-LZTS2 Antibody (CAB14598)
- SKU:
- CAB14598
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
| 抗体名: | Anti-LZTS2 Antibody |
| 抗体コード: | CAB14598 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 470-669 of human LZTS2 (NP_115805.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | DU145, HT-29, HeLa, U-87MG, MCF7, Mouse brain, Rat kidney, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 470-669 of human LZTS2 (NP_115805.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | ELVA LRVA LREA RATL RVSE GRAR GLQE AARA RELE LEAC SQEL QRHR QEAE QLRE KAGQ LDAE AAGL REPP VPPA TADP FLLA ESDE AKVQ RAAA GVGG SLRA QVER LRVE LQRE RRRG EEQR DSFE GERL AWQA EKEQ VIRY QKQL QHNY IQMY RRNR QLEQ ELQQ LSLE LEAR ELAD LGLA EQAP CICL EEIT ATEI |
| 遺伝子ID: | 84445 |
| Uniprot: | Q9BRK4 |
| セルラーロケーション: | Cytoplasm, centrosome, cytoskeleton, microtubule organizing center |
| 計算された分子量: | 72kDa |
| 観察された分子量: | 73kDa |
| 同義語: | LZTS2, LAPSER1 |
| バックグラウンド: | The protein encoded by this gene belongs to the leucine zipper tumor suppressor family of proteins, which function in transcription regulation and cell cycle control. This family member can repress beta-catenin-mediated transcriptional activation and is a negative regulator of the Wnt signaling pathway. It negatively regulates microtubule severing at centrosomes, and is necessary for central spindle formation and cytokinesis completion. It is implicated in cancer, where it may inhibit cell proliferation and decrease susceptibility to tumor development. Alternative splicing of this gene results in multiple transcript variants. |
| UniProt Protein Function: | LZTS2: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. Belongs to the LZTS2 family. |
| UniProt Protein Details: | Protein type:Nuclear export Chromosomal Location of Human Ortholog: 10q24 Molecular Function:protein binding |
| NCBI Summary: | The protein encoded by this gene belongs to the leucine zipper tumor suppressor family of proteins, which function in transcription regulation and cell cycle control. This family member can repress beta-catenin-mediated transcriptional activation and is a negative regulator of the Wnt signaling pathway. It negatively regulates microtubule severing at centrosomes, and is necessary for central spindle formation and cytokinesis completion. It is implicated in cancer, where it may inhibit cell proliferation and decrease susceptibility to tumor development. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015] |
| UniProt Code: | Q9BRK4 |
| NCBI GenInfo Identifier: | 46396501 |
| NCBI Gene ID: | 84445 |
| NCBI Accession: | Q9BRK4.2 |
| UniProt Secondary Accession: | Q9BRK4,Q8N3I0, Q96J79, Q96JL2, B1AL14, D3DR72, |
| UniProt Related Accession: | Q9BRK4 |
| Molecular Weight: | 72,759 Da |
| NCBI Full Name: | Leucine zipper putative tumor suppressor 2 |
| NCBI Synonym Full Names: | leucine zipper tumor suppressor 2 |
| NCBI Official Symbol: | LZTS2 |
| NCBI Official Synonym Symbols: | LAPSER1 |
| NCBI Protein Information: | leucine zipper putative tumor suppressor 2 |
| UniProt Protein Name: | Leucine zipper putative tumor suppressor 2 |
| UniProt Synonym Protein Names: | Protein LAPSER1 |
| Protein Family: | Leucine zipper putative tumor suppressor |
| UniProt Gene Name: | LZTS2 |
| UniProt Entry Name: | LZTS2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using LZTS2 antibody (CAB14598) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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