Anti-LYZ Antibody (CAB12919)

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SKU:
CAB12919
Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
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Description

system_update_altデータシートsystem_update_alt安全性データシート
抗体名:Anti-LYZ Antibody
抗体コード:CAB12919
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB
反応性:Human, Mouse
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 19-148 of human LYZ (NP_000230.1).
申し込み:WB
推奨希釈:WB 1:500 - 1:2000
反応性:Human, Mouse
ポジティブサンプル:
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 19-148 of human LYZ (NP_000230.1).
精製方法:Affinity purification
ストレージバッファ:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:KVFE RCEL ARTL KRLG MDGY RGIS LANW MCLA KWES GYNT RATN YNAG DRST DYGI FQIN SRYW CNDG KTPG AVNA CHLS CSAL LQDN IADA VACA KRVV RDPQ GIRA WVAW RNRC QNRD VRQY VQGC GV
遺伝子ID:4069
Uniprot:P61626
セルラーロケーション:Secreted
計算された分子量:16kDa
観察された分子量:Refer to figures
同義語:LYZ, LYZF1, LZM, lysozyme
バックグラウンド:This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis.
UniProt Protein Function:LYZ: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte- macrophage system and enhance the activity of immunoagents. Defects in LYZ are a cause of amyloidosis type 8 (AMYL8); also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. Belongs to the glycosyl hydrolase 22 family.
UniProt Protein Details:

Protein type:EC 3.2.1.17; Endoplasmic reticulum; Secreted, signal peptide; Vesicle; Secreted; Hydrolase

Chromosomal Location of Human Ortholog: 12q15

Cellular Component: extracellular space; extracellular region

Molecular Function:identical protein binding; lysozyme activity

Biological Process: retinal homeostasis; metabolic process; cytolysis; defense response to bacterium; inflammatory response

Disease: Amyloidosis, Familial Visceral

NCBI Summary:This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. [provided by RefSeq, Oct 2014]
UniProt Code:P61626
NCBI GenInfo Identifier:48428995
NCBI Gene ID:4069
NCBI Accession:P61626.1
UniProt Related Accession:P61626
Molecular Weight:~ 17kDa
NCBI Full Name:Lysozyme C
NCBI Synonym Full Names:lysozyme
NCBI Official Symbol:LYZ  
NCBI Official Synonym Symbols:LZM; LYZF1  
NCBI Protein Information:lysozyme C
UniProt Protein Name:Lysozyme C
UniProt Synonym Protein Names:1,4-beta-N-acetylmuramidase C
UniProt Gene Name:LYZ  
UniProt Entry Name:LYSC_HUMAN
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