Anti-LTBP1 Antibody (CAB15287)
- SKU:
- CAB15287
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-LTBP1 Antibody |
| 抗体コード: | CAB15287 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1290-1540 of human LTBP1 (NP_996826.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:200 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | LO2 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1290-1540 of human LTBP1 (NP_996826.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | CELL SGVC GEAF CENV EGSF LCVC ADEN QEYS PMTG QCRS RTST DLDV DVDQ PKEE KKEC YYNL NDAS LCDN VLAP NVTK QECC CTSG AGWG DNCE IFPC PVLG TAEF TEMC PKGK GFVP AGES SSEA GGEN YKDA DECL LFGQ EICK NGFC LNTR PGYE CYCK QGTY YDPV KLQC FDMD ECQD PSSC IDGQ CVNT EGSY NCFC THPM VLDA SEKR CIRP AESN EQIE ETDV YQDL CWEH LSDE YVCS RPL |
| 遺伝子ID: | 4052 |
| Uniprot: | Q14766 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 147kDa/152kDa/153kDa/186kDa |
| 観察された分子量: | 150kDa |
| 同義語: | LTBP1 |
| バックグラウンド: | The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| UniProt Protein Function: | LTBP1: May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extra cellular matrix (ECM). Belongs to the LTBP family. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Chaperone; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 2p22-p21 Cellular Component: extracellular matrix; extracellular region; microfibril; protein complex Molecular Function:microfibril binding; protein binding; transforming growth factor beta binding |
| NCBI Summary: | The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14766 |
| NCBI GenInfo Identifier: | 290457687 |
| NCBI Gene ID: | 4052 |
| NCBI Accession: | Q14766.4 |
| UniProt Secondary Accession: | Q14766,P22064, Q53SD8, Q53SF3, Q53SG1, Q59HF7, Q8TD95 A1L3V1, |
| UniProt Related Accession: | Q14766 |
| Molecular Weight: | 153,006 Da |
| NCBI Full Name: | Latent-transforming growth factor beta-binding protein 1 |
| NCBI Synonym Full Names: | latent transforming growth factor beta binding protein 1 |
| NCBI Official Symbol: | LTBP1 |
| NCBI Protein Information: | latent-transforming growth factor beta-binding protein 1 |
| UniProt Protein Name: | Latent-transforming growth factor beta-binding protein 1 |
| UniProt Synonym Protein Names: | Transforming growth factor beta-1-binding protein 1; TGF-beta1-BP-1 |
| Protein Family: | Latent-transforming growth factor beta-binding protein |
| UniProt Gene Name: | LTBP1 |
| UniProt Entry Name: | LTBP1_HUMAN |
 | Western blot analysis of extracts of LO2 cells, using LTBP1 antibody (CAB15287) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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