Anti-LRRFIP2 Antibody (CAB17046)
- SKU:
- CAB17046
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-LRRFIP2 Antibody |
| 抗体コード: | CAB17046 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 150-340 of human LRRFIP2 (NP_060194.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Mouse heart, Mouse skeletal muscle, Rat heart |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 150-340 of human LRRFIP2 (NP_060194.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VIEE QEEQ MAEF YREN EEKS KELE RQKH MCSV LQHK MEEL KEGL RQRD ELIE KHGL VIIP DGTP NGDV SHEP VAGA ITVV SQEA AQVL ESAG EGPL DVRL RKLA GEKE ELLS QIRK LKLQ LEEE RQKC SRND GTVG DLAG LQNG SDLQ FIEM QRDA NRQI SEYK FKLS KAEQ DITT LEQS ISRL EGQV LRY |
| 遺伝子ID: | 9209 |
| Uniprot: | Q9Y608 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | 47kDa |
 | Western blot - LRRFIP2 Rabbit pAb (CAB17046) |
| 同義語: | LRRFIP2, HUFI-2 |
| バックグラウンド: | The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex. |
| UniProt Protein Function: | LRRFIP2: May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta- catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. Belongs to the LRRFIP family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 3p22.2 Molecular Function:protein binding; LRR domain binding Biological Process: Wnt receptor signaling pathway |
| UniProt Code: | Q9Y608 |
| NCBI GenInfo Identifier: | 5453726 |
| NCBI Gene ID: | 9209 |
| NCBI Accession: | NP_006300 |
| UniProt Secondary Accession: | Q9Y608,Q68CV3, Q9NXH5, A8K649, A8MXR0, B4DY63, |
| UniProt Related Accession: | Q9Y608 |
| Molecular Weight: | |
| NCBI Full Name: | leucine-rich repeat flightless-interacting protein 2 isoform 1 |
| NCBI Synonym Full Names: | leucine rich repeat (in FLII) interacting protein 2 |
| NCBI Official Symbol: | LRRFIP2 |
| NCBI Official Synonym Symbols: | HUFI-2 |
| NCBI Protein Information: | leucine-rich repeat flightless-interacting protein 2; LRR FLII-interacting protein 2 |
| UniProt Protein Name: | Leucine-rich repeat flightless-interacting protein 2 |
| UniProt Gene Name: | LRRFIP2 |
| UniProt Entry Name: | LRRF2_HUMAN |