Anti-LRPAP1 Antibody (CAB3004)
- SKU:
- CAB3004
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-LRPAP1 Antibody |
| 抗体コード: | CAB3004 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide of human LRPAP1 |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | K-562, THP-1, HepG2 |
| 免疫原: | A synthetic peptide of human LRPAP1 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 4043 |
| Uniprot: | P30533 |
| セルラーロケーション: | Cell surface, Cytoplasm, Endoplasmic reticulum |
| 計算された分子量: | 41kDa |
| 観察された分子量: | 39kDa |
| 同義語: | LRPAP1, A2MRAP, A2RAP, HBP44, MRAP, MYP23, RAP, alpha-2-MRAP |
| バックグラウンド: | This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | LRPAP1: Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330. In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis. Belongs to the alpha-2-MRAP family. |
| UniProt Protein Details: | Protein type:Receptor, misc. Chromosomal Location of Human Ortholog: 4p16.3 Cellular Component: cell surface; endoplasmic reticulum; extracellular region; plasma membrane; integral to membrane; vesicle Molecular Function:heparin binding; receptor antagonist activity; protein binding; low-density lipoprotein receptor binding; unfolded protein binding; asialoglycoprotein receptor activity Biological Process: vesicle-mediated transport; receptor-mediated endocytosis; protein folding; negative regulation of protein binding Disease: Myopia 23, Autosomal Recessive |
| NCBI Summary: | This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013] |
| UniProt Code: | P30533 |
| NCBI GenInfo Identifier: | 231539 |
| NCBI Gene ID: | 4043 |
| NCBI Accession: | P30533.1 |
| UniProt Related Accession: | P30533 |
| Molecular Weight: | |
| NCBI Full Name: | Alpha-2-macroglobulin receptor-associated protein |
| NCBI Synonym Full Names: | LDL receptor related protein associated protein 1 |
| NCBI Official Symbol: | LRPAP1 |
| NCBI Official Synonym Symbols: | RAP; MRAP; A2RAP; HBP44; MYP23; A2MRAP; alpha-2-MRAP |
| NCBI Protein Information: | alpha-2-macroglobulin receptor-associated protein |
| UniProt Protein Name: | Alpha-2-macroglobulin receptor-associated protein |
| UniProt Synonym Protein Names: | Low density lipoprotein receptor-related protein-associated protein 1; RAP |
| UniProt Gene Name: | LRPAP1 |
| UniProt Entry Name: | AMRP_HUMAN |
 | Western blot analysis of extracts of various cell lines, using LRPAP1 antibody (CAB3004) at 1:200 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human liver cancer using LRPAP1 Antibody (CAB3004) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat brain using LRPAP1 Antibody (CAB3004) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse brain using LRPAP1 Antibody (CAB3004) at dilution of 1:200 (40x lens). |
 | Immunofluorescence analysis of NIH-3T3 cells using LRPAP1 Polyclonal Antibody (CAB3004) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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