Anti-LONP1 Antibody (CAB4293)
- SKU:
- CAB4293
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-LONP1 Antibody |
| 抗体コード: | CAB4293 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-400 of human LONP1 (NP_004784.2). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | A-549, HL-60, LO2, HT-1080, BT-474, Mouse heart, Mouse kidney, Mouse liver, Rat kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-400 of human LONP1 (NP_004784.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VFPH LPLI AITR NPVF PRFI KIIE VKNK KLVE LLRR KVRL AQPY VGVF LKRD DSNE SDVV ESLD EIYH TGTF AQIH EMQD LGDK LRMI VMGH RRVH ISRQ LEVE PEEP EAEN KHKP RRKS KRGK KEAE DELS ARHP AELA MEPT PELP AEVL MVEV ENVV HEDF QVTE EVKA LTAE IVKT IRDI IALN PLYR ESVL QMMQ AGQR VVDN PIYL SDMG AALT GAES HELQ DVLE ETNI PKRL YKAL SLLK KEFE LSKL QQRL GREV EEKI KQTH RKYL LQEQ L |
| 遺伝子ID: | 9361 |
| Uniprot: | P36776 |
| セルラーロケーション: | Mitochondrion matrix |
| 計算された分子量: | 85kDa/100kDa/106kDa |
| 観察された分子量: | 106kDa |
| 同義語: | LONP1, CODASS, LON, LONP, LonHS, PIM1, PRSS15, hLON |
| バックグラウンド: | This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia (PMID:18378094). Alternatively spliced transcript variants have been found for this gene. |
| UniProt Protein Function: | PRSS15: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single- stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site- specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters. Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein. Belongs to the peptidase S16 family. |
| UniProt Protein Details: | Protein type:RNA-binding; DNA-binding; Mitochondrial; EC 3.4.21.-; Protease Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: mitochondrion; membrane; mitochondrial matrix; cytoplasm Molecular Function:G-quadruplex DNA binding; protein binding; single-stranded RNA binding; sequence-specific DNA binding; ATP-dependent peptidase activity; serine-type endopeptidase activity; ADP binding; ATP binding; single-stranded DNA binding Biological Process: mitochondrion organization and biogenesis; mitochondrial genome maintenance; proteolysis involved in cellular protein catabolic process; misfolded or incompletely synthesized protein catabolic process; response to hypoxia; response to hormone stimulus; chaperone-mediated protein complex assembly; mitochondrial DNA metabolic process; protein homooligomerization; response to aluminum ion; aging Disease: Codas Syndrome |
| UniProt Code: | P36776 |
| NCBI GenInfo Identifier: | 12644239 |
| NCBI Gene ID: | |
| NCBI Accession: | P36776.2 |
| Molecular Weight: | |
| NCBI Full Name: | Lon protease homolog, mitochondrial |
| UniProt Protein Name: | Lon protease homolog, mitochondrial |
| UniProt Synonym Protein Names: | LONHsLon protease-like protein; Mitochondrial ATP-dependent protease Lon; Serine protease 15 |
| UniProt Gene Name: | LONP1 |
| UniProt Entry Name: | LONM_HUMAN |
 | Western blot analysis of extracts of various cell lines, using LONP1 antibody (CAB4293) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
 | Immunohistochemistry of paraffin-embedded mouse kidney using LONP1 Rabbit pAb (CAB4293) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat kidney using LONP1 Rabbit pAb (CAB4293) at dilution of 1:100 (40x lens). |
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