Anti-LMTK2 Antibody (CAB15403)
- SKU:
- CAB15403
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-LMTK2 Antibody |
| 抗体コード: | CAB15403 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1100-1300 of human LMTK2 (NP_055731.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:200 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1100-1300 of human LMTK2 (NP_055731.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | YRDS AYFS DNDS EPEK RSEE VPGT SPSA LVLV QEQP LPEP VLPE QSPA AQDS CLEA RKSQ PDES CLSA LHNS SDLE LRAT PEPA QTGV PQQV HPTE DEAS SPWS VLNA ELSS GDDF ETQD DRPC TLAS TGTN TNEL LAYT NSAL DKSL SSHS EGPK LKEP DIEG KYLG KLGV SGML DLSE DGMD ADEE DENS DDSD EDLR A |
| 遺伝子ID: | 22853 |
| Uniprot: | Q8IWU2 |
| セルラーロケーション: | Membrane, Multi-pass membrane protein |
| 計算された分子量: | 164kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | LMTK2, AATYK2, BREK, KPI-2, KPI2, LMR2, PPP1R100, cprk, hBREK |
| バックグラウンド: | The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. |
| UniProt Protein Function: | Lmr2: a tyrosine kinase of the Lmr family that apparently phosphorylates Serine and Threonine residues. Associates with PP1C and Inh2 to form a regulatory complex that localizes to membranes. Enriched in brain and muscle. Inhibited in living cells by addition of nerve growth factor or serum. Appears to be inhibited by Cdk5/p35. |
| UniProt Protein Details: | Protein type:EC 2.7.11.1; Protein kinase, TK; Membrane protein, multi-pass; Kinase, protein; Membrane protein, integral; Protein kinase, tyrosine (receptor); TK group; Lmr family Chromosomal Location of Human Ortholog: 7q21.3 Cellular Component: early endosome; Golgi apparatus; integral to membrane; perinuclear region of cytoplasm; recycling endosome Molecular Function:protein binding; protein phosphatase inhibitor activity; protein serine/threonine kinase activity Biological Process: early endosome to late endosome transport; endocytic recycling; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation; receptor recycling; transferrin transport |
| NCBI Summary: | The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009] |
| UniProt Code: | Q8IWU2 |
| NCBI GenInfo Identifier: | 145559492 |
| NCBI Gene ID: | 22853 |
| NCBI Accession: | Q8IWU2.2 |
| UniProt Secondary Accession: | Q8IWU2,Q75MG7, Q9UPS3, A4D272, |
| UniProt Related Accession: | Q8IWU2 |
| Molecular Weight: | 164,900 Da |
| NCBI Full Name: | Serine/threonine-protein kinase LMTK2 |
| NCBI Synonym Full Names: | lemur tyrosine kinase 2 |
| NCBI Official Symbol: | LMTK2 |
| NCBI Official Synonym Symbols: | BREK; KPI2; LMR2; cprk; KPI-2; hBREK; AATYK2; PPP1R100 |
| NCBI Protein Information: | serine/threonine-protein kinase LMTK2 |
| UniProt Protein Name: | Serine/threonine-protein kinase LMTK2 |
| UniProt Synonym Protein Names: | Apoptosis-associated tyrosine kinase 2; Brain-enriched kinase; hBREK; CDK5/p35-regulated kinase; CPRK; Kinase/phosphatase/inhibitor 2; Lemur tyrosine kinase 2; Serine/threonine-protein kinase KPI-2 |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | LMTK2 |
| UniProt Entry Name: | LMTK2_HUMAN |
View AllClose