Anti-LLGL2 Antibody (CAB18366)
- SKU:
- CAB18366
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
| 抗体名: | Anti-LLGL2 Antibody |
| 抗体コード: | CAB18366 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human LLGL2. |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | HeLa |
| 免疫原: | Recombinant protein of human LLGL2. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 3993 |
| Uniprot: | Q6P1M3 |
| セルラーロケーション: | |
| 計算された分子量: | 113kDa |
| 観察された分子量: | 113kDa |
 | Western blot - LLGL2 Rabbit pAb (CAB18366) |
| 同義語: | HGL, Hugl-2, LGL2, LLGL2 |
| バックグラウンド: |
| UniProt Protein Function: | LLGL2: Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity. Belongs to the WD repeat L(2)GL family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell cycle regulation Chromosomal Location of Human Ortholog: 17q25.1 Cellular Component: cortical actin cytoskeleton; cytoplasm; intracellular membrane-bound organelle; nucleoplasm; plasma membrane Molecular Function:GTPase activator activity; PDZ domain binding; protein binding; Rab GTPase binding; syntaxin binding Biological Process: cortical actin cytoskeleton organization and biogenesis; establishment of spindle orientation; neurogenesis; regulation of establishment and/or maintenance of cell polarity; regulation of exocytosis; regulation of Notch signaling pathway; regulation of protein secretion |
| NCBI Summary: | The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q6P1M3 |
| NCBI GenInfo Identifier: | 93204600 |
| NCBI Gene ID: | 3993 |
| NCBI Accession: | Q6P1M3.2 |
| UniProt Secondary Accession: | Q6P1M3,Q14521, Q9BR62, |
| UniProt Related Accession: | Q6P1M3 |
| Molecular Weight: | 39,668 Da |
| NCBI Full Name: | Lethal(2) giant larvae protein homolog 2 |
| NCBI Synonym Full Names: | LLGL2, scribble cell polarity complex component |
| NCBI Official Symbol: | LLGL2 |
| NCBI Official Synonym Symbols: | HGL; LGL2; Hugl-2 |
| NCBI Protein Information: | lethal(2) giant larvae protein homolog 2 |
| UniProt Protein Name: | Lethal(2) giant larvae protein homolog 2 |
| UniProt Synonym Protein Names: | HGL |
| Protein Family: | Lethal(2) giant larvae protein |
| UniProt Gene Name: | LLGL2 |
| UniProt Entry Name: | L2GL2_HUMAN |