Anti-LIN9 Antibody (CAB17851)
- SKU:
- CAB17851
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-LIN9 Antibody |
| 抗体コード: | CAB17851 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 350-470 of human LIN9 (NP_775106.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | Mouse testis |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 350-470 of human LIN9 (NP_775106.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | TLGG FPVE FLIQ VTRL SKIL MIKK EHIK KLRE MNTE AEKL KSYS MPIS IEFQ RRYA TIVL ELEQ LNKD LNKV LHKV QQYC YELA PDQG LQPA DQPT DMRR RCEE EAQE IVRH ANSS TGQP C |
| 遺伝子ID: | 286826 |
| Uniprot: | Q5TKA1 |
| セルラーロケーション: | |
| 計算された分子量: | 57kDa/61kDa/63kDa |
| 観察された分子量: | 70kDa |
 | Western blot - LIN9 Rabbit pAb (CAB17851) |
| 同義語: | BARA, BARPsv, Lin-9, TGS, TGS1, TGS2, LIN9 |
| バックグラウンド: | This gene encodes a tumor suppressor protein that inhibits DNA synthesis and oncogenic transformation through association with the retinoblastoma 1 protein. The encoded protein also interacts with a complex of other cell cycle regulators to repress cell cycle-dependent gene expression in non-dividing cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012] |
| UniProt Protein Function: | LIN9: a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition. Component of the DREAM complex composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBBP4, RBL2, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with RB1. Three alternative spliced human isoforms have been reported. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; Transcription, coactivator/corepressor; Tumor suppressor Chromosomal Location of Human Ortholog: 1q42.12 Cellular Component: nucleoplasm Molecular Function:protein binding Biological Process: regulation of cell cycle |
| NCBI Summary: | This gene encodes a tumor suppressor protein that inhibits DNA synthesis and oncogenic transformation through association with the retinoblastoma 1 protein. The encoded protein also interacts with a complex of other cell cycle regulators to repress cell cycle-dependent gene expression in non-dividing cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012] |
| UniProt Code: | Q5TKA1 |
| NCBI GenInfo Identifier: | 74708186 |
| NCBI Gene ID: | 286826 |
| NCBI Accession: | Q5TKA1.1 |
| UniProt Secondary Accession: | Q5TKA1,Q5U5L8, Q5U7E1, Q6PI55, Q6ZTV4, Q7Z3J1, |
| UniProt Related Accession: | Q5TKA1 |
| Molecular Weight: | 57,733 Da |
| NCBI Full Name: | Protein lin-9 homolog |
| NCBI Synonym Full Names: | lin-9 DREAM MuvB core complex component |
| NCBI Official Symbol: | LIN9 |
| NCBI Official Synonym Symbols: | TGS; BARA; TGS1; TGS2; Lin-9; BARPsv |
| NCBI Protein Information: | protein lin-9 homolog |
| UniProt Protein Name: | Protein lin-9 homolog |
| UniProt Synonym Protein Names: | Beta subunit-associated regulator of apoptosis; TUDOR gene similar protein; Type I interferon receptor beta chain-associated protein; pRB-associated protein |
| Protein Family: | Protein |
| UniProt Gene Name: | LIN9 |
| UniProt Entry Name: | LIN9_HUMAN |