Anti-LIN7C Antibody (CAB16544)
- SKU:
- CAB16544
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-LIN7C Antibody |
| 抗体コード: | CAB16544 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human LIN7C (NP_060832.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HeLa, HepG2, U-251MG, Mouse kidney, Rat kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human LIN7C (NP_060832.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MAAL GEPV RLER DICR AIEL LEKL QRSG EVPP QKLQ ALQR VLQS EFCN AVRE VYEH VYET VDIS SSPE VR |
| 遺伝子ID: | 55327 |
| Uniprot: | Q9NUP9 |
| セルラーロケーション: | Basolateral cell membrane, Cell junction, Cell membrane, Peripheral membrane protein, postsynaptic cell membrane, postsynaptic density, synapse, synaptosome, tight junction |
| 計算された分子量: | 21kDa |
| 観察された分子量: | 25kDa |
| 同義語: | LIN7C, LIN-7-C, LIN-7C, MALS-3, MALS3, VELI3 |
| バックグラウンド: |
| UniProt Protein Function: | LIN7C: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. Belongs to the lin-7 family. |
| UniProt Protein Details: | Protein type:Cell adhesion Chromosomal Location of Human Ortholog: 11p14 Cellular Component: basolateral plasma membrane; cytoplasm; intercellular junction; plasma membrane Molecular Function:cytoskeletal protein binding; protein domain specific binding Biological Process: exocytosis; maintenance of epithelial cell polarity; morphogenesis of an epithelial sheet; neurotransmitter secretion |
| UniProt Code: | Q9NUP9 |
| NCBI GenInfo Identifier: | 59798474 |
| NCBI Gene ID: | 55327 |
| NCBI Accession: | Q9NUP9.1 |
| UniProt Related Accession: | Q9NUP9 |
| Molecular Weight: | 21,834 Da |
| NCBI Full Name: | Protein lin-7 homolog C |
| NCBI Synonym Full Names: | lin-7 homolog C, crumbs cell polarity complex component |
| NCBI Official Symbol: | LIN7C |
| NCBI Official Synonym Symbols: | MALS3; VELI3; LIN-7C; MALS-3; LIN-7-C |
| NCBI Protein Information: | protein lin-7 homolog C |
| UniProt Protein Name: | Protein lin-7 homolog C |
| UniProt Synonym Protein Names: | Mammalian lin-seven protein 3; MALS-3; Vertebrate lin-7 homolog 3; Veli-3 |
| Protein Family: | Protein |
| UniProt Gene Name: | LIN7C |
| UniProt Entry Name: | LIN7C_HUMAN |
 | Western blot analysis of extracts of various cell lines, using LIN7C antibody (CAB16544) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s. |
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