Anti-LIMD1 Antibody (CAB17585)
- SKU:
- CAB17585
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-LIMD1 Antibody |
| 抗体コード: | CAB17585 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human LIMD1 (NP_055055.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | MCF7, HeLa, HepG2, Mouse lung, Mouse heart |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human LIMD1 (NP_055055.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MDKY DDLG LEAS KFIE DLNM YEAS KDGL FRVD KGAG NNPE FEET RRVF ATKM AKIH LQQQ QQQL LQEE TLPR GSRG PVNG GGRL GPQA RWEV VGSK LTVD GAAK PPLA ASTG APGA VTTL AAGQ PPYP PQEQ RSRP YLHG TRHG SQDC GSRE SLAT SEMS AFHQ PGPC EDPS CLTH GDYY DNLS LASP KWGD KPGV SPSI |
| 遺伝子ID: | 8994 |
| Uniprot: | Q9UGP4 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | 72kDa |
 | Western blot - LIMD1 Polyclonal Antibody (CAB17585) |
| 同義語: | LIMD1 |
| バックグラウンド: |
| UniProt Protein Function: | LIMD1: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG- dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1- responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. Belongs to the zyxin/ajuba family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Tumor suppressor Chromosomal Location of Human Ortholog: 3p21.3 Cellular Component: adherens junction; cytoplasm; focal adhesion; nucleus Molecular Function:protein binding; transcription corepressor activity Biological Process: cell migration; cytoplasmic mRNA processing body assembly; cytoskeleton organization and biogenesis; miRNA-mediated gene silencing; multicellular organismal development; negative regulation of osteoblast differentiation; negative regulation of transcription, DNA-dependent; osteoblast development; phosphorylation; regulation of cell shape; regulation of transcription, DNA-dependent; response to hypoxia; signal transduction |
| UniProt Code: | Q9UGP4 |
| NCBI GenInfo Identifier: | 47605932 |
| NCBI Gene ID: | 8994 |
| NCBI Accession: | Q9UGP4.1 |
| UniProt Secondary Accession: | Q9UGP4,Q17RQ1, Q9BQQ9, Q9NQ47, |
| UniProt Related Accession: | Q9UGP4 |
| Molecular Weight: | 72,190 Da |
| NCBI Full Name: | LIM domain-containing protein 1 |
| NCBI Synonym Full Names: | LIM domains containing 1 |
| NCBI Official Symbol: | LIMD1 |
| NCBI Protein Information: | LIM domain-containing protein 1 |
| UniProt Protein Name: | LIM domain-containing protein 1 |
| Protein Family: | LIM domain-containing protein |
| UniProt Gene Name: | LIMD1 |
| UniProt Entry Name: | LIMD1_HUMAN |