| UniProt Protein Function: | Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1. Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1. |
| NCBI Summary: | This gene encodes a member of a large family of proteins which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Mutations in this gene cause combined pituitary hormone deficiency 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015] |
| UniProt Code: | Q9UBR4 |
| NCBI GenInfo Identifier: | 1393428460 |
| NCBI Gene ID: | 8022 |
| NCBI Accession: | NP_001350675.1 |
| UniProt Secondary Accession: | Q9UBR4,Q5TB39, Q5TB40, Q9NZB5, Q9P0I8, Q9P0I9, |
| UniProt Related Accession: | Q9UBR4 |
| Molecular Weight: | 43,978 Da |
| NCBI Full Name: | LIM/homeobox protein Lhx3 isoform c |
| NCBI Synonym Full Names: | LIM homeobox 3 |
| NCBI Official Symbol: | LHX3 |
| NCBI Official Synonym Symbols: | LIM3; CPHD3; M2-LHX3 |
| NCBI Protein Information: | LIM/homeobox protein Lhx3 |
| UniProt Protein Name: | LIM/homeobox protein Lhx3 |
| Protein Family: | LIM/homeobox protein |
| UniProt Gene Name: | LHX3 |
