| UniProt Protein Function: | LGR5: a leucine-rich repeat-containing G-protein-coupled receptor. Receptor for R-spondins, potent stimulators of adult stem cell proliferation. A marker of cycling, long-lived and multipotent adult stem cell populations. Target gene of Wnt signaling. A Wnt receptor component that enhances Wnt signaling by soluble R-spondin proteins. Intestinal Lgr5+ stem cells give rise throughout life to proliferation of cells in crypts, which migrate along the crypt-villus axis, differentiating into five main cell types. Wnt signaling plays a crucial role in the proliferation and differentiation of these crypt epithelial cells. Two isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Chromosomal Location of Human Ortholog: 12q21.1 Cellular Component: integral to plasma membrane; plasma membrane; trans-Golgi network membrane Molecular Function:G-protein coupled receptor activity; protein binding; transmembrane receptor activity |
| NCBI Summary: | The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015] |
| UniProt Code: | O75473 |
| NCBI GenInfo Identifier: | 21542118 |
| NCBI Gene ID: | 8549 |
| NCBI Accession: | O75473.1 |
| UniProt Secondary Accession: | O75473,Q4VAM0, Q4VAM2, Q9UP75, D8MCT0, |
| UniProt Related Accession: | O75473 |
| Molecular Weight: | 100kDa |
| NCBI Full Name: | Leucine-rich repeat-containing G-protein coupled receptor 5 |
| NCBI Synonym Full Names: | leucine rich repeat containing G protein-coupled receptor 5 |
| NCBI Official Symbol: | LGR5 |
| NCBI Official Synonym Symbols: | FEX; HG38; GPR49; GPR67; GRP49 |
| NCBI Protein Information: | leucine-rich repeat-containing G-protein coupled receptor 5 |
| UniProt Protein Name: | Leucine-rich repeat-containing G-protein coupled receptor 5 |
| UniProt Synonym Protein Names: | G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38 |
| Protein Family: | Leucine-rich repeat-containing G-protein coupled receptor |
| UniProt Gene Name: | LGR5 |
