Anti-LGR4 Antibody (CAB12658)
- SKU:
- CAB12658
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-LGR4 Antibody |
| 抗体コード: | CAB12658 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 320-540 of human LGR4 (NP_060960.2). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human |
| ポジティブサンプル: | SGC-7901, 293T, LO2 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 320-540 of human LGR4 (NP_060960.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | HLES LTLT GTKI SSIP NNLC QEQK MLRT LDLS YNNI RDLP SFNG CHAL EEIS LQRN QIYQ IKEG TFQG LISL RILD LSRN LIHE IHSR AFAT LGPI TNLD VSFN ELTS FPTE GLNG LNQL KLVG NFKL KEAL AAKD FVNL RSLS VPYA YQCC AFWG CDSY ANLN TEDN SLQD HSVA QEKG TADA ANVT STLE NEEH SQII IHCT PSTG AFKP CEYL LGSW M |
| 遺伝子ID: | 55366 |
| Uniprot: | Q9BXB1 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 101kDa/104kDa |
| 観察された分子量: | 104kDa |
| 同義語: | LGR4, BNMD17, GPR48 |
| バックグラウンド: |
| UniProt Protein Function: | LGR4: a leucine-rich repeat-containing G-protein-coupled receptor. Receptor for R-spondins, potent stimulators of adult stem cell proliferation. A Wnt receptor component that enhances Wnt signaling by soluble R-spondin proteins. Plays an essential role during homeostasis of the adult mouse intestine. |
| UniProt Protein Details: | Protein type:GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Chromosomal Location of Human Ortholog: 11p14.1 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:G-protein coupled receptor activity; protein binding; transmembrane receptor activity Biological Process: bone mineralization; bone remodeling; circadian regulation of gene expression; negative regulation of cytokine secretion; negative regulation of toll-like receptor signaling pathway; osteoblast differentiation; spermatogenesis Disease: Bone Mineral Density Quantitative Trait Locus 17 |
| NCBI Summary: | The protein encoded by this gene is a G-protein coupled receptor that binds R-spondins and activates the Wnt signaling pathway. This Wnt signaling pathway activation is necessary for proper development of many organs of the body. [provided by RefSeq, Oct 2016] |
| UniProt Code: | Q9BXB1 |
| NCBI GenInfo Identifier: | 212286375 |
| NCBI Gene ID: | 55366 |
| NCBI Accession: | Q9BXB1.2 |
| UniProt Secondary Accession: | Q9BXB1,Q8N537, Q9NYD1, A6NCH3, G5E9B3, |
| UniProt Related Accession: | Q9BXB1 |
| Molecular Weight: | 104kDa |
| NCBI Full Name: | Leucine-rich repeat-containing G-protein coupled receptor 4 |
| NCBI Synonym Full Names: | leucine rich repeat containing G protein-coupled receptor 4 |
| NCBI Official Symbol: | LGR4 |
| NCBI Official Synonym Symbols: | GPR48; BNMD17 |
| NCBI Protein Information: | leucine-rich repeat-containing G-protein coupled receptor 4 |
| UniProt Protein Name: | Leucine-rich repeat-containing G-protein coupled receptor 4 |
| UniProt Synonym Protein Names: | G-protein coupled receptor 48 |
| Protein Family: | Leucine-rich repeat-containing G-protein coupled receptor |
| UniProt Gene Name: | LGR4 |
 | Western blot analysis of extracts of various cell lines, using LGR4 antibody (CAB12658) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 120s. |
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