Anti-Leupaxin Antibody (CAB9803)
- SKU:
- CAB9803
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-Leupaxin Antibody |
| 抗体コード: | CAB9803 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human LPXN (NP_004802.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Jurkat, Mouse spleen, Rat testis |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human LPXN (NP_004802.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MEEL DALL EELE RSTL QDSD EYSN PAPL PLDQ HSRK ETNL DETS EILS IQDN TSPL PAQL VYTT NIQE LNVY SEAQ EPKE SPPP SKTS AAAQ LDEL MAHL TEMQ AKVA VRAD AGKK HLPD KQDH KASL DSML GGLE QELQ DLGI ATVP KG |
| 遺伝子ID: | 9404 |
| Uniprot: | O60711 |
| セルラーロケーション: | Cell junction, Cell membrane, Cell projection, Cytoplasm, Nucleus, focal adhesion, perinuclear region, podosome |
| 計算された分子量: | 43kDa |
| 観察された分子量: | 43kDa |
| 同義語: | LPXN, LDPL, leupaxin |
| バックグラウンド: | The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
| UniProt Protein Function: | leupaxin: a LIM domain-containing cytoplasmic protein preferentially expressed in hematopoietic cells. Homologous to the focal adhesion protein, paxillin. Associates with PYK2, a member of focal adhesion kinase family, it may participate in signaling at sites of adhesion.. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold; Cytoskeletal; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 11q12.1 Cellular Component: cell projection; focal adhesion; membrane; perinuclear region of cytoplasm; cytoplasm; plasma membrane; podosome; nucleus Molecular Function:protein binding; zinc ion binding; transcription cofactor activity Biological Process: regulation of cell adhesion mediated by integrin; transcription, DNA-dependent; regulation of transcription, DNA-dependent; negative regulation of B cell receptor signaling pathway; protein complex assembly; negative regulation of cell adhesion; signal transduction; cell adhesion |
| NCBI Summary: | The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009] |
| UniProt Code: | O60711 |
| NCBI GenInfo Identifier: | 8134557 |
| NCBI Gene ID: | 9404 |
| NCBI Accession: | O60711.1 |
| UniProt Secondary Accession: | O60711,Q53FW6, Q6FI07, B2R8B4, B4DV71, |
| UniProt Related Accession: | O60711 |
| Molecular Weight: | 43,750 Da |
| NCBI Full Name: | Leupaxin |
| NCBI Synonym Full Names: | leupaxin |
| NCBI Official Symbol: | LPXN |
| NCBI Official Synonym Symbols: | LDPL |
| NCBI Protein Information: | leupaxin |
| UniProt Protein Name: | Leupaxin |
| Protein Family: | Leupaxin |
| UniProt Gene Name: | LPXN |
| UniProt Entry Name: | LPXN_HUMAN |
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