| UniProt Protein Function: | LDB1: Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. May play a role in the development of motor neurons. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. Belongs to the LDB family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 10q24-q25 Cellular Component: leading edge; nuclear chromatin; nucleus; protein complex; transcription factor complex Molecular Function:enzyme binding; LIM domain binding; protein binding; protein homodimerization activity; transcription corepressor activity Biological Process: negative regulation of erythrocyte differentiation; negative regulation of transcription, DNA-dependent; neuron differentiation; positive regulation of hemoglobin biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; regulation of cell migration; regulation of focal adhesion formation; regulation of kinase activity; regulation of RNA elongation |
| UniProt Code: | Q86U70 |
| NCBI GenInfo Identifier: | 158518615 |
| NCBI Gene ID: | 8861 |
| NCBI Accession: | Q86U70.2 |
| UniProt Secondary Accession: | Q86U70,O75479, O96010, Q1EQX1, Q9UGM4, B4DUC4, |
| UniProt Related Accession: | Q86U70 |
| Molecular Weight: | 42,809 Da |
| NCBI Full Name: | LIM domain-binding protein 1 |
| NCBI Synonym Full Names: | LIM domain binding 1 |
| NCBI Official Symbol: | LDB1 |
| NCBI Official Synonym Symbols: | NLI; CLIM2; LDB-1; CLIM-2 |
| NCBI Protein Information: | LIM domain-binding protein 1 |
| UniProt Protein Name: | LIM domain-binding protein 1 |
| UniProt Synonym Protein Names: | Carboxyl-terminal LIM domain-binding protein 2; CLIM-2; LIM domain-binding factor CLIM2; hLdb1; Nuclear LIM interactor |
| Protein Family: | LIM domain-binding protein |
| UniProt Gene Name: | LDB1 |
| UniProt Entry Name: | LDB1_HUMAN |
