| UniProt Protein Function: | LBP: Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. The LBP/LPS complex seems to interact with the CD14 receptor. Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 20q11.23 Cellular Component: extracellular space; cell surface; extracellular region Molecular Function:protein binding; lipopolysaccharide binding; receptor binding Biological Process: positive regulation of tumor necrosis factor biosynthetic process; detection of molecule of bacterial origin; positive regulation of toll-like receptor 4 signaling pathway; positive regulation of interleukin-6 production; response to lipopolysaccharide; negative regulation of tumor necrosis factor production; positive regulation of tumor necrosis factor production; defense response to Gram-negative bacterium; leukocyte chemotaxis during inflammatory response; positive regulation of chemokine production; positive regulation of interleukin-8 production; lipopolysaccharide transport; defense response to Gram-positive bacterium; macrophage activation during immune response; lipopolysaccharide-mediated signaling pathway; toll-like receptor signaling pathway; acute-phase response; innate immune response; cellular defense response; opsonization; toll-like receptor 4 signaling pathway; positive regulation of macrophage activation |
| NCBI Summary: | The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012] |
| UniProt Code: | P18428 |
| NCBI GenInfo Identifier: | 116242615 |
| NCBI Gene ID: | 3929 |
| NCBI Accession: | P18428.3 |
| UniProt Secondary Accession: | P18428,O43438, Q92672, Q9H403, Q9UD66, B2R938, |
| UniProt Related Accession: | P18428 |
| Molecular Weight: | 53,384 Da |
| NCBI Full Name: | Lipopolysaccharide-binding protein |
| NCBI Synonym Full Names: | lipopolysaccharide binding protein |
| NCBI Official Symbol: | LBP |
| NCBI Official Synonym Symbols: | BPIFD2 |
| NCBI Protein Information: | lipopolysaccharide-binding protein; LPS-binding protein; BPI fold containing family D, member 2 |
| UniProt Protein Name: | Lipopolysaccharide-binding protein |
| Protein Family: | Lipopolysaccharide-binding protein |
| UniProt Gene Name: | LBP |
| UniProt Entry Name: | LBP_HUMAN |
