Anti-LAX1 Antibody (CAB12218)
- SKU:
- CAB12218
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | Anti-LAX1 Antibody |
| 抗体コード: | CAB12218 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 77-398 of human LAX1 (NP_060243.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | Raji, Mouse liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 77-398 of human LAX1 (NP_060243.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MPLL TLPQ TRQR AKNI YDIL PWRQ EDLG RHES RSMR IFST ESLL SRNS ESPE HVPS QAGN AFQE HTAH IHAT EYAV GIYD NAMV PQMC GNLT PSAH CINV RASR DCAS ISSE DSHD YVNV PTAE EIAE TLAS TKSP SRNL FVLP STQK LEFT EERD EGCG DAGD CTSL YSPG AEDS DSLS NGEG SSQI SNDY VNMT GLDL SAIQ ERQL WVAF QCCR DYEN VPAA DPSG SQQQ AEKD VPSS NIGH VEDK TDDP GTHV QCVK RTFL ASGD YADF QPFT QSED SQMK HREE MSNE DSSD YENV LTAK LGGR DSEQ GPGT QLLP DE |
| 遺伝子ID: | 54900 |
| Uniprot: | Q8IWV1 |
| セルラーロケーション: | Cell membrane, Single-pass type III membrane protein |
| 計算された分子量: | 35kDa/42kDa/44kDa |
| 観察された分子量: | 44kDa |
| 同義語: | LAX1, LAX |
| バックグラウンド: |
| UniProt Protein Function: | LAX1: Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold; Membrane protein, integral Chromosomal Location of Human Ortholog: 1q32.1 Cellular Component: cytosol; Golgi apparatus; integral to membrane; lipid raft; membrane; plasma membrane Molecular Function:protein binding; protein kinase binding; SH2 domain binding Biological Process: B cell activation; immune response; inactivation of MAPK activity; negative regulation of T cell activation |
| UniProt Code: | Q8IWV1 |
| NCBI GenInfo Identifier: | 74728197 |
| NCBI Gene ID: | 54900 |
| NCBI Accession: | Q8IWV1.1 |
| UniProt Secondary Accession: | Q8IWV1,Q6NSZ6, Q9NXB4, B7Z744, J3KP69, |
| UniProt Related Accession: | Q8IWV1 |
| Molecular Weight: | 44kDa |
| NCBI Full Name: | Lymphocyte transmembrane adapter 1 |
| NCBI Synonym Full Names: | lymphocyte transmembrane adaptor 1 |
| NCBI Official Symbol: | LAX1 |
| NCBI Official Synonym Symbols: | LAX |
| NCBI Protein Information: | lymphocyte transmembrane adapter 1 |
| UniProt Protein Name: | Lymphocyte transmembrane adapter 1 |
| UniProt Synonym Protein Names: | Linker for activation of X cells; Membrane-associated adapter protein LAX |
| Protein Family: | Lymphocyte transmembrane adapter |
| UniProt Gene Name: | LAX1 |
 | Western blot analysis of extracts of various cell lines, using LAX1 antibody (CAB12218) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |