Anti-LATS2 Antibody (CAB17390)
- SKU:
- CAB17390
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
| 抗体名: | Anti-LATS2 Antibody |
| 抗体コード: | CAB17390 |
| 抗体サイズ: | 50µL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide of human LATS2. |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: |
| 免疫原: | A synthetic peptide of human LATS2. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 26524 |
| Uniprot: | Q9NRM7 |
| セルラーロケーション: | Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center, spindle pole |
| 計算された分子量: | 120kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | LATS2, KPM |
| バックグラウンド: | This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. |
| UniProt Protein Function: | LATS2: an AGC kinase of the NDR family of kinases. A tumor suppressor of the LATS family. Plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Inhibits cell growth at the G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Interacts with and is phosphorylated by STK6. Ectopic expression induces apoptosis in lung cancer cell lines. Negatively regulates androgen receptor, and is downregulated in prostate cancer |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Kinase, protein; Tumor suppressor; Protein kinase, AGC; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); AGC group; NDR family Chromosomal Location of Human Ortholog: 13q12.11 Cellular Component: cytoplasm; cytosol; microtubule organizing center; nucleus; spindle pole Molecular Function:ATP binding; protein binding; protein serine/threonine kinase activity Biological Process: G1/S transition of mitotic cell cycle; hormone-mediated signaling; negative regulation of cyclin-dependent protein kinase activity; peptidyl-serine phosphorylation; positive regulation of apoptosis; protein amino acid phosphorylation; regulation of organ growth |
| NCBI Summary: | This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NRM7 |
| NCBI GenInfo Identifier: | 212276441 |
| NCBI Gene ID: | 26524 |
| NCBI Accession: | Q9NRM7.2 |
| UniProt Secondary Accession: | Q9NRM7,Q9P2X1, B1AM47, |
| UniProt Related Accession: | Q9NRM7 |
| Molecular Weight: | 120,136 Da |
| NCBI Full Name: | Serine/threonine-protein kinase LATS2 |
| NCBI Synonym Full Names: | large tumor suppressor kinase 2 |
| NCBI Official Symbol: | LATS2 |
| NCBI Official Synonym Symbols: | KPM |
| NCBI Protein Information: | serine/threonine-protein kinase LATS2 |
| UniProt Protein Name: | Serine/threonine-protein kinase LATS2 |
| UniProt Synonym Protein Names: | Kinase phosphorylated during mitosis protein; Large tumor suppressor homolog 2; Serine/threonine-protein kinase kpm; Warts-like kinase |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | LATS2 |
| UniProt Entry Name: | LATS2_HUMAN |
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