Anti-LAMTOR1 Antibody (CAB19983)[KO Validated]
![Anti-LAMTOR1 Antibody (CAB19983)[KO Validated]](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/608x608/products/22236/22084/anti-lamtor1-antibody-cab19983ko-validated__70342__71270.1645805102.jpg?c=1 "Anti-LAMTOR1 Antibody (CAB19983)[KO Validated]")
- SKU:
- CAB19983
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
![Anti-LAMTOR1 Antibody (CAB19983)[KO Validated]](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/1280x1280/products/22236/22084/anti-lamtor1-antibody-cab19983ko-validated__70342__71270.1645805102.jpg?c=1&imbypass=on "Anti-LAMTOR1 Antibody (CAB19983)[KO Validated]")
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Description
| 抗体名: | Anti-LAMTOR1 Antibody [KO Validated] |
| 抗体コード: | CAB19983 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human LAMTOR1. |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:1000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HeLa |
| 免疫原: | Recombinant protein of human LAMTOR1. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 55004 |
| Uniprot: | Q6IAA8 |
| セルラーロケーション: | Cell membrane, Cytoplasmic side, Late endosome membrane, Lipid-anchor, Lysosome membrane |
| 計算された分子量: | 17kDa |
| 観察された分子量: | 18KDa |
![Anti-LAMTOR1 Antibody [KO Validated] (CAB19983)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/l/758/A19983_1__91392.jpg) | Western blot analysis of extracts from normal (control) and LAMTOR1 knockout (KO) HeLa cells, using LAMTOR1 antibody (CAB19983) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
| 同義語: | LAMTOR1, C11orf59, PDRO, Ragulator1, p18, p27RF-Rho |
| バックグラウンド: |
| UniProt Protein Function: | LAMTOR1: Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, recruits the Rag GTPases and the mTORC1 complex to lysosomes, a key step in activation of the TOR signaling cascade by amino acids. Directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation. Part of the Ragulator complex composed of LAMTOR1, LAMTOR2 and LAMTOR3. Interacts with LAMTOR2 and LAMTOR3; the interaction is direct. The Ragulator complex interacts with both the mTORC1 complex and heterodimers of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD. Interacts with RRAGB and RRAGD; the interaction is direct indicating that it probably constitutes the main RAG-interacting subunit of the Ragulator complex. Interacts with MMP14. Interacts with CDKN1B; prevents the interaction of CDKN1B with RHOA leaving RHOA in a form accessible to activation by ARHGEF2. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 11q13.4 Cellular Component: late endosome membrane; lipid raft; lysosomal membrane; lysosome; plasma membrane Molecular Function:GTPase binding; guanyl-nucleotide exchange factor activity; protein binding; protein complex scaffold Biological Process: cell cycle arrest; cell growth; cholesterol homeostasis; endosome localization; endosome organization and biogenesis; lysosome localization; lysosome organization and biogenesis; macroautophagy; neutrophil degranulation; positive regulation of MAPKKK cascade; positive regulation of TOR signaling pathway; regulation of receptor recycling |
| UniProt Code: | Q6IAA8 |
| NCBI GenInfo Identifier: | 125863645 |
| NCBI Gene ID: | 55004 |
| NCBI Accession: | Q6IAA8.2 |
| UniProt Secondary Accession: | Q6IAA8,Q8WZ09, Q9NWT0, |
| UniProt Related Accession: | Q6IAA8 |
| Molecular Weight: | 18kDa |
| NCBI Full Name: | Ragulator complex protein LAMTOR1 |
| NCBI Synonym Full Names: | late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 |
| NCBI Official Symbol: | LAMTOR1 |
| NCBI Official Synonym Symbols: | p18; PDRO; C11orf59; p27RF-Rho; Ragulator1 |
| NCBI Protein Information: | ragulator complex protein LAMTOR1 |
| UniProt Protein Name: | Ragulator complex protein LAMTOR1 |
| UniProt Synonym Protein Names: | Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1; Lipid raft adaptor protein p18; Protein associated with DRMs and endosomes; p27Kip1-releasing factor from RhoA; p27RF-Rho |
| Protein Family: | Ragulator complex protein |
| UniProt Gene Name: | LAMTOR1 |