Anti-LAMB3 Antibody (CAB8127)
- SKU:
- CAB8127
- Product type:
- Antibody
- Application:
- IHC
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | LAMB3 Rabbit Polyclonal Antibody |
| 抗体コード: | CAB8127 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | IHC |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 18-230 of human LAMB3 (NP_000219.2). |
| 申し込み: | IHC |
| 推奨希釈: | IHC 1:50 - 1:100 |
| 反応性: | Human |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 18-230 of human LAMB3 (NP_000219.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | QQAC SRGA CYPP VGDL LVGR TRFL RASS TCGL TKPE TYCT QYGE WQMK CCKC DSRQ PHNY YSHR VENV ASSS GPMR WWQS QNDV NPVS LQLD LDRR FQLQ EVMM EFQG PMPA GMLI ERSS DFGK TWRV YQYL AADC TSTF PRVR QGRP QSWQ DVRC QSLP QRPN ARLN GGKV QLNL MDLV SGIP ATQS QKIQ EVGE ITNL RVNF TRLA PVPQ R |
| 遺伝子ID: | 3914 |
| Uniprot: | Q13751 |
| セルラーロケーション: | Secreted, basement membrane, extracellular matrix, extracellular space |
| 計算された分子量: | 129kDa |
| 観察された分子量: |
| 同義語: | LAMB3, AI1A, BM600-125KDA, LAM5, LAMNB1 |
| バックグラウンド: | The product encoded by this gene is a laminin that belongs to a family of basement membrane proteins. This protein is a beta subunit laminin, which together with an alpha and a gamma subunit, forms laminin-5. Mutations in this gene cause epidermolysis bullosa junctional Herlitz type, and generalized atrophic benign epidermolysis bullosa, diseases that are characterized by blistering of the skin. Multiple alternatively spliced transcript variants that encode the same protein have been found for this gene. |
| UniProt Protein Function: | LAMB3: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Defects in LAMB3 are a cause of epidermolysis bullosa junctional Herlitz type (H-JEB); also known as junctional epidermolysis bullosa Herlitz-Pearson type. JEB defines a group of blistering skin diseases characterized by tissue separation which occurs within the dermo-epidermal basement membrane. H-JEB is a severe, infantile and lethal form. Death occurs usually within the first six months of life. Occasionally, children survive to teens. H-JEB is marked by bullous lesions at birth and extensive denudation of skin and mucous membranes that may be hemorrhagic. Defects in LAMB3 are a cause of generalized atrophic benign epidermolysis bullosa (GABEB). GABEB is a non- lethal, adult form of junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and tooth abnormalities. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted Chromosomal Location of Human Ortholog: 1q32 Cellular Component: laminin-5 complex; extracellular region Molecular Function:protein binding; protein complex binding; structural molecule activity Biological Process: extracellular matrix disassembly; hemidesmosome assembly; extracellular matrix organization and biogenesis; epidermis development; brown fat cell differentiation; cell adhesion Disease: Epidermolysis Bullosa, Junctional, Non-herlitz Type; Epidermolysis Bullosa, Junctional, Herlitz Type; Amelogenesis Imperfecta, Type Ia |
| NCBI Summary: | The product encoded by this gene is a laminin that belongs to a family of basement membrane proteins. This protein is a beta subunit laminin, which together with an alpha and a gamma subunit, forms laminin-5. Mutations in this gene cause epidermolysis bullosa junctional Herlitz type, and generalized atrophic benign epidermolysis bullosa, diseases that are characterized by blistering of the skin. Multiple alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13751 |
| NCBI GenInfo Identifier: | 62868215 |
| NCBI Gene ID: | 3914 |
| NCBI Accession: | NP_000219.2 |
| UniProt Secondary Accession: | Q13751,O14947, Q14733, Q9UJK4, Q9UJL1, D3DT88, |
| UniProt Related Accession: | Q13751 |
| Molecular Weight: | 129,572 Da |
| NCBI Full Name: | laminin subunit beta-3 |
| NCBI Synonym Full Names: | laminin, beta 3 |
| NCBI Official Symbol: | LAMB3 |
| NCBI Official Synonym Symbols: | LAM5; LAMNB1; BM600-125KDA |
| NCBI Protein Information: | laminin subunit beta-3; nicein-125kDa; kalinin-140kDa; kalinin B1 chain; laminin B1k chain; laminin S B3 chain; nicein subunit beta; kalinin subunit beta; epiligrin subunit bata; laminin-5 subunit beta; laminin, beta 3 (nicein (125kD), kalinin (140kD), BM600 (125kD)) |
| UniProt Protein Name: | Laminin subunit beta-3 |
| UniProt Synonym Protein Names: | Epiligrin subunit bata; Kalinin B1 chain; Kalinin subunit beta; Laminin B1k chain; Laminin-5 subunit beta; Nicein subunit beta |
| Protein Family: | Laminin |
| UniProt Gene Name: | LAMB3 |
| UniProt Entry Name: | LAMB3_HUMAN |
 | Immunohistochemistry of paraffin-embedded human stomach using LAMB3 antibody (CAB8127) at dilution of 1:100 (40x lens). |
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