Anti-LAIR1 Antibody (CAB10120)
- SKU:
- CAB10120
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | Anti-LAIR1 Antibody |
| 抗体コード: | CAB10120 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human LAIR1 |
| 申し込み: | WB |
| 推奨希釈: | WB 1:1000 - 1:4000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | B cells, Jurkat, HL-60, Raji, Mouse brain, Mouse liver, Mouse lung, Rat liver |
| 免疫原: | Recombinant protein of human LAIR1 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 3903 |
| Uniprot: | Q6GTX8 |
| セルラーロケーション: | Cell membrane, Single-pass type I membrane protein |
| 計算された分子量: | 23kDa/29kDa/31kDa |
| 観察された分子量: | 35kDa |
| 同義語: | LAIR1, CD305, LAIR-1 |
| バックグラウンド: | The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. The encoded protein has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | LAIR-1: an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region called the leukocyte receptor cluster, which contains at least 25 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.4 Cellular Component: plasma membrane Molecular Function:protein binding Biological Process: regulation of immune response |
| NCBI Summary: | The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. The encoded protein has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] |
| UniProt Code: | Q6GTX8 |
| NCBI GenInfo Identifier: | 74736490 |
| NCBI Gene ID: | 3903 |
| NCBI Accession: | Q6GTX8.1 |
| UniProt Related Accession: | Q6GTX8 |
| Molecular Weight: | 23,049 Da |
| NCBI Full Name: | Leukocyte-associated immunoglobulin-like receptor 1 |
| NCBI Synonym Full Names: | leukocyte associated immunoglobulin like receptor 1 |
| NCBI Official Symbol: | LAIR1 |
| NCBI Official Synonym Symbols: | CD305; LAIR-1 |
| NCBI Protein Information: | leukocyte-associated immunoglobulin-like receptor 1 |
| UniProt Protein Name: | Leukocyte-associated immunoglobulin-like receptor 1 |
| UniProt Synonym Protein Names: | CD_antigen: CD305 |
| Protein Family: | Leukocyte-associated immunoglobulin-like receptor |
| UniProt Gene Name: | LAIR1 |
| UniProt Entry Name: | LAIR1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using LAIR1 antibody (CAB10120) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |