UniProt Protein Function: | Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism (PubMed:28329758). Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism (PubMed:28329758). It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein (PubMed:28329758). Acts as a tumor suppressor that has the ability to inhibit proliferation of multiple types of breast cancer cells: probably by promoting decreased levels of PISD, thereby affecting mitochondrial lipid metabolism (PubMed:28329758). |
NCBI Summary: | This gene encodes a mitochondrially-localized protein that has sequence similarity to prokaryotic beta-lactamases. Many of the residues responsible for beta-lactamase activity are not conserved in this protein, suggesting it may have a different enzymatic function. Increased expression of the related mouse gene was found to be associated with obesity. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Dec 2013] |
UniProt Code: | P83111 |
NCBI GenInfo Identifier: | 568384811 |
NCBI Gene ID: | 114294 |
NCBI Accession: | NP_001275514.1 |
UniProt Secondary Accession: | P83111,P83096, |
UniProt Related Accession: | P83111 |
Molecular Weight: | Predicted MW: 61kDa |
NCBI Full Name: | serine beta-lactamase-like protein LACTB, mitochondrial isoform c |
NCBI Synonym Full Names: | lactamase beta |
NCBI Official Symbol: | LACTB |
NCBI Official Synonym Symbols: | G24; MRPL56 |
NCBI Protein Information: | serine beta-lactamase-like protein LACTB, mitochondrial |
UniProt Protein Name: | Serine beta-lactamase-like protein LACTB, mitochondrial |
Protein Family: | Serine beta-lactamase-like protein |
UniProt Gene Name: | LACTB |