Anti-L3MBTL1 Antibody (CAB7090)
- SKU:
- CAB7090
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-L3MBTL1 Antibody |
抗体コード: | CAB7090 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | IF |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 533-772 of human L3MBTL1 (NP_056293.4). |
申し込み: | IF |
推奨希釈: | IF 1:50 - 1:100 |
反応性: | Human |
ポジティブサンプル: |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 533-772 of human L3MBTL1 (NP_056293.4). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | PLSY RSLP HTRT SKYS FHHR KCPT PGCD GSGH VTGK FTAH HCLS GCPL AERN QSRL KAEL SDSE ASAR KKNL SGFS PRKK PRHH GRIG RPPK YRKI PQED FQTL TPDV VHQS LFMS ALSA HPDR SLSV CWEQ HCKL LPGV AGIS ASTV AKWT IDEV FGFV QTLT GCED QARL FKDE ARIV RVTH VSGK TLVW TVAQ LGDL VCSD HLQE GKGI LETG VHSL LCSL PTHL LAKL SFAS DSQY |
遺伝子ID: | 26013 |
Uniprot: | Q9Y468 |
セルラーロケーション: | Nucleus |
計算された分子量: | 43kDa/82kDa/83kDa/85kDa/92kDa |
観察された分子量: |
同義語: | L3MBTL1, H-L(3)MBT, L3MBTL, ZC2HC3, dJ138B7.3 |
バックグラウンド: | This gene represents a polycomb group gene. The encoded protein functions to regulate gene activity, likely via chromatin modification. The encoded protein may also be necessary for mitosis. Alternatively spliced transcript variants encoding different isoforms have been identified. |
UniProt Protein Function: | Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis. |
NCBI Summary: | This gene represents a polycomb group gene. The encoded protein functions to regulate gene activity, likely via chromatin modification. The encoded protein may also be necessary for mitosis. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010] |
UniProt Code: | Q9Y468 |
NCBI GenInfo Identifier: | 325511398 |
NCBI Gene ID: | 26013 |
NCBI Accession: | Q9Y468.3 |
UniProt Secondary Accession: | Q9Y468,Q5H8Y8, Q5H8Y9, Q8IUV7, Q9H1E6, Q9H1G5, Q9UG06 Q9UJB9, Q9Y4C9, B4DRC9, E1P5W7, |
UniProt Related Accession: | Q9Y468 |
Molecular Weight: | 92,297 Da |
NCBI Full Name: | Lethal(3)malignant brain tumor-like protein 1 |
NCBI Synonym Full Names: | l(3)mbt-like 1 (Drosophila) |
NCBI Official Symbol: | L3MBTL1 |
NCBI Official Synonym Symbols: | L3MBTL; ZC2HC3; H-L(3)MBT; dJ138B7.3 |
NCBI Protein Information: | lethal(3)malignant brain tumor-like protein 1 |
UniProt Protein Name: | Lethal(3)malignant brain tumor-like protein 1 |
UniProt Synonym Protein Names: | L(3)mbt protein homolog; L3MBTL1 |
Protein Family: | Lethal(3)malignant brain tumor-like protein |
UniProt Gene Name: | L3MBTL1 |
UniProt Entry Name: | LMBL1_HUMAN |
View AllClose