Anti-KRT3 Antibody (CAB10118)
- SKU:
- CAB10118
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-KRT3 Antibody |
| 抗体コード: | CAB10118 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 230-390 of human KRT3 (NP_476429.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | NCI-H460 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 230-390 of human KRT3 (NP_476429.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | WNLL QQQG TSSI SGTN NLEP LFEN HINY LRSY LDNI LGER GRLD SELK NMED LVED FKKK YEDE INKR TAAE NEFV TLKK DVDS AYMN KVEL QAKV DALI DEID FLRT LYDA ELSQ MQSH ISDT SVVL SMDN NRSL DLDS IIAE VRAQ YEDI AQRS KAEA E |
| 遺伝子ID: | 3850 |
| Uniprot: | P12035 |
| セルラーロケーション: | |
| 計算された分子量: | 64kDa |
| 観察された分子量: | 65kDa |
| 同義語: | KRT3, CK3, K3, keratin 3 |
| バックグラウンド: | The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal epithelium with family member KRT12 and mutations in these genes have been associated with Meesmann's Corneal Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. |
| UniProt Protein Function: | K3: a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K12. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 12q13.13 Cellular Component: keratin filament Molecular Function:structural molecule activity Biological Process: epithelial cell differentiation; intermediate filament cytoskeleton organization and biogenesis Disease: Corneal Dystrophy, Meesmann |
| NCBI Summary: | The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal epithelium with family member KRT12 and mutations in these genes have been associated with Meesmann's Corneal Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P12035 |
| NCBI GenInfo Identifier: | 313104225 |
| NCBI Gene ID: | 3850 |
| NCBI Accession: | P12035.3 |
| UniProt Secondary Accession: | P12035,Q701L8, A6NIS2, |
| UniProt Related Accession: | P12035 |
| Molecular Weight: | 64,417 Da |
| NCBI Full Name: | Keratin, type II cytoskeletal 3 |
| NCBI Synonym Full Names: | keratin 3 |
| NCBI Official Symbol: | KRT3 |
| NCBI Official Synonym Symbols: | K3; CK3 |
| NCBI Protein Information: | keratin, type II cytoskeletal 3 |
| UniProt Protein Name: | Keratin, type II cytoskeletal 3 |
| UniProt Synonym Protein Names: | 65 kDa cytokeratin; Cytokeratin-3; CK-3; Keratin-3; K3; Type-II keratin Kb3 |
| Protein Family: | Keratin |
| UniProt Gene Name: | KRT3 |
| UniProt Entry Name: | K2C3_HUMAN |
 | Western blot analysis of extracts of H460 cells, using KRT3 Antibody (CAB10118) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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