Anti-KRT2 Antibody (CAB10375)
- SKU:
- CAB10375
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-KRT2 Antibody |
| 抗体コード: | CAB10375 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human KRT2 (NP_000414.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HeLa, Mouse liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human KRT2 (NP_000414.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MSCQ ISCK SRGR GGGG GGFR GFSS GSAV VSGG SRRS TSSF SCLS RHGG GGGG FGGG GFGS RSLV GLGG TKSI SISV AGGG GGFG AAGG FGGR GGGF GGGS SFGG GSGF SGGG FGGG GFGG GRFG GFGG PGGV GGLG GPGG FGPG GYPG GIHE VSVN QSLL QPLN VKVD PEIQ NVKA QERE QIKT LNNK FASF IDKV RFLE QQNQ VLQT KWEL LQQM NVGT |
| 遺伝子ID: | 3849 |
| Uniprot: | P35908 |
| セルラーロケーション: | |
| 計算された分子量: | 65kDa |
| 観察された分子量: | 65kDa |
| 同義語: | KRT2, CK-2e, K2e, KRT2A, KRT2E, KRTE, keratin 2 |
| バックグラウンド: | The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. |
| UniProt Protein Function: | K2: a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 12q13.13 Cellular Component: cornified envelope; cytosol; extracellular space; intermediate filament; membrane; nucleus Molecular Function:protein binding; structural constituent of cytoskeleton; structural constituent of epidermis Biological Process: epidermis development; keratinization; keratinocyte activation; keratinocyte migration; keratinocyte proliferation; peptide cross-linking Disease: Ichthyosis, Bullous Type |
| NCBI Summary: | The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P35908 |
| NCBI GenInfo Identifier: | 239938650 |
| NCBI Gene ID: | 3849 |
| NCBI Accession: | P35908.2 |
| UniProt Secondary Accession: | P35908,Q4VAQ2, |
| UniProt Related Accession: | P35908 |
| Molecular Weight: | 65kDa |
| NCBI Full Name: | Keratin, type II cytoskeletal 2 epidermal |
| NCBI Synonym Full Names: | keratin 2 |
| NCBI Official Symbol: | KRT2 |
| NCBI Official Synonym Symbols: | K2e; KRTE; CK-2e; KRT2A; KRT2E |
| NCBI Protein Information: | keratin, type II cytoskeletal 2 epidermal |
| UniProt Protein Name: | Keratin, type II cytoskeletal 2 epidermal |
| UniProt Synonym Protein Names: | Cytokeratin-2e; CK-2e; Epithelial keratin-2e; Keratin-2 epidermis; Keratin-2e; K2e; Type-II keratin Kb2 |
| Protein Family: | Keratin |
| UniProt Gene Name: | KRT2 |
 | Western blot analysis of extracts of various cell lines, using KRT2 antibody (CAB10375) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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