Anti-KRT10 Antibody (CAB7908)
- SKU:
- CAB7908
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-KRT10 Antibody |
| 抗体コード: | CAB7908 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide of human KRT10 |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | H-460 |
| 免疫原: | A synthetic peptide of human KRT10 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 3858 |
| Uniprot: | P13645 |
| セルラーロケーション: | |
| 計算された分子量: | 58kDa |
| 観察された分子量: | 59kDa |
| 同義語: | KRT10, BCIE, BIE, CK10, EHK, K10, KPP |
| バックグラウンド: | This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. |
| UniProt Protein Function: | K10: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K1. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 17q21 Cellular Component: cytoplasm; extracellular space; membrane; nucleus Biological Process: keratinocyte differentiation Disease: Epidermolytic Hyperkeratosis; Erythroderma, Ichthyosiform, Congenital Reticular; Ichthyosis, Cyclic, With Epidermolytic Hyperkeratosis |
| NCBI Summary: | This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P13645 |
| NCBI GenInfo Identifier: | 269849769 |
| NCBI Gene ID: | 3858 |
| NCBI Accession: | P13645.6 |
| UniProt Secondary Accession: | P13645,Q14664, Q8N175, |
| UniProt Related Accession: | P13645 |
| Molecular Weight: | 58,827 Da |
| NCBI Full Name: | Keratin, type I cytoskeletal 10 |
| NCBI Synonym Full Names: | keratin 10 |
| NCBI Official Symbol: | KRT10 |
| NCBI Official Synonym Symbols: | BIE; EHK; K10; KPP; BCIE; CK10 |
| NCBI Protein Information: | keratin, type I cytoskeletal 10 |
| UniProt Protein Name: | Keratin, type I cytoskeletal 10 |
| UniProt Synonym Protein Names: | Cytokeratin-10; CK-10; Keratin-10; K10 |
| Protein Family: | Keratin |
| UniProt Gene Name: | KRT10 |
| UniProt Entry Name: | K1C10_HUMAN |
 | Western blot analysis of extracts of H-460 cells, using KRT10 antibody (CAB7908) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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