Anti-KLRC4 Antibody (CAB14807)
- SKU:
- CAB14807
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-KLRC4 Antibody |
| 抗体コード: | CAB14807 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-55 of human KLRC4 (NP_038459.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | A-549, NCI-H460, 293T, Mouse lung, Mouse kidney, Rat kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-55 of human KLRC4 (NP_038459.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MNKQ RGTY SEVS LAQD PKRQ QRKL KGNK ISIS GTKQ EIFQ VELN LQNA SSDH QGN |
| 遺伝子ID: | 8302 |
| Uniprot: | O43908 |
| セルラーロケーション: | Membrane, Single-pass type II membrane protein |
| 計算された分子量: | 18kDa |
| 観察された分子量: | 14kDa |
| 同義語: | KLRC4, NKG2-F, NKG2F |
| バックグラウンド: | Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. This gene is a member of the NKG2 group of genes that are expressed primarily in natural killer (NK) cells. These family members encode transmembrane proteins that are characterized by a type II membrane orientation (have an extracellular C-terminus) and the presence of a C-type lectin domain. This family member is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. Read-through transcription exists between this gene and the downstream KLRK1 (killer cell lectin-like receptor subfamily K, member 1) family member. |
| UniProt Protein Function: | KLRC4: May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 12p13.2-p12.3 Cellular Component: integral to membrane Biological Process: cellular defense response |
| NCBI Summary: | Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. This gene is a member of the NKG2 group of genes that are expressed primarily in natural killer (NK) cells. These family members encode transmembrane proteins that are characterized by a type II membrane orientation (have an extracellular C-terminus) and the presence of a C-type lectin domain. This family member is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. Read-through transcription exists between this gene and the downstream KLRK1 (killer cell lectin-like receptor subfamily K, member 1) family member. [provided by RefSeq, Dec 2010] |
| UniProt Code: | O43908 |
| NCBI GenInfo Identifier: | 7710124 |
| NCBI Gene ID: | 8302 |
| NCBI Accession: | NP_038459.1 |
| UniProt Secondary Accession: | O43908,O60851, |
| UniProt Related Accession: | O43908 |
| Molecular Weight: | 18,234 Da |
| NCBI Full Name: | NKG2-F type II integral membrane protein |
| NCBI Synonym Full Names: | killer cell lectin like receptor C4 |
| NCBI Official Symbol: | KLRC4 |
| NCBI Official Synonym Symbols: | NKG2F; NKG2-F |
| NCBI Protein Information: | NKG2-F type II integral membrane protein |
| UniProt Protein Name: | NKG2-F type II integral membrane protein |
| UniProt Synonym Protein Names: | NK cell receptor F; NKG2-F-activating NK receptor |
| Protein Family: | NKG2-F type II integral membrane protein |
| UniProt Gene Name: | KLRC4 |
| UniProt Entry Name: | NKG2F_HUMAN |
 | Western blot analysis of extracts of various cell lines, using KLRC4 antibody (CAB14807) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunofluorescence analysis of Jurkat cells using KLRC4 Polyclonal Antibody (CAB14807) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of mouse spleen using KLRC4 Polyclonal Antibody (CAB14807) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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