Anti-KLKB1 Antibody (RACO0360)
- SKU:
- RACO0360
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| 商品名: | KLKB1 Antibody |
| Product SKU: | RACO0360 |
| サイズ: | 50ul |
| 宿主種: | Homo sapiens (Human) |
| 申し込み: | ELISA, IHC |
| 推奨される希釈: | IHC:1:50-1:200 |
| 反応性: | Human |
| 免疫原: | A synthesized peptide derived from human KLKB1 |
| 憲法: | Liquid |
| ストレージバッファ: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 精製方法: | Affinity-chromatography |
| 抗体のクローン性: | Monoclonal |
| アイソタイプ: | Rabbit IgG |
| Conjugate: | Non-conjugated |
| バックグラウンド: | The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. |
| シノニム: | Plasma kallikrein (EC 3.4.21.34) (Fletcher factor) (Kininogenin) (Plasma prekallikrein) (PKK) [Cleaved into: Plasma kallikrein heavy chain, Plasma kallikrein light chain], KLKB1, KLK3 |
 | IHC image of RACO0360 diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
| UniProt Protein Function: | KLKB1: The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency); also known as Fletcher factor deficiency. This disorder is a blood coagulation defect. Belongs to the peptidase S1 family. Plasma kallikrein subfamily. |
| UniProt Protein Details: | Protein type:Secreted; EC 3.4.21.34; Protease; Secreted, signal peptide Chromosomal Location of Human Ortholog: 4q35 Cellular Component: extracellular space; plasma membrane; extracellular region Molecular Function:protein binding; serine-type endopeptidase activity Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; fibrinolysis; positive regulation of fibrinolysis; zymogen activation; proteolysis; blood coagulation; blood coagulation, intrinsic pathway; Factor XII activation; plasminogen activation Disease: Prekallikrein Deficiency |
| NCBI Summary: | Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P03952 |
| NCBI GenInfo Identifier: | 125184 |
| NCBI Gene ID: | 3818 |
| NCBI Accession: | P03952.1 |
| UniProt Secondary Accession: | P03952,Q17RE8, Q17RE9, Q4W5C3, A6NH96, B2R8H9, |
| UniProt Related Accession: | P03952 |
| Molecular Weight: | 71,370 Da |
| NCBI Full Name: | Plasma kallikrein |
| NCBI Synonym Full Names: | kallikrein B, plasma (Fletcher factor) 1 |
| NCBI Official Symbol: | KLKB1 |
| NCBI Official Synonym Symbols: | PPK; KLK3 |
| NCBI Protein Information: | plasma kallikrein; kininogenin; Fletcher factor; plasma prekallikrein; plasma kallikrein heavy chain; plasma kallikrein light chain |
| UniProt Protein Name: | Plasma kallikrein |
| UniProt Synonym Protein Names: | Fletcher factor; Kininogenin; Plasma prekallikrein |
| Protein Family: | Protein kinase |
| UniProt Gene Name: | KLKB1 |
| UniProt Entry Name: | KLKB1_HUMAN |